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    Aspdh aspartate dehydrogenase domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aspdhprovided by RGD
    Official Full Name
    aspartate dehydrogenase domain containingprovided by RGD
    Primary source
    RGD:1310111
    See related
    AllianceGenome:RGD:1310111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310111
    Summary
    Predicted to enable NADP binding activity and aspartate dehydrogenase activity. Predicted to be involved in NAD biosynthetic process. Orthologous to human ASPDH (aspartate dehydrogenase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 305.0) and Kidney (RPKM 198.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aspdh in Genome Data Viewer
    Location:
    1q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104094983..104097244)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94956327..94960722)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100471066..100473327)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 3 Neighboring gene uncharacterized LOC108349570 Neighboring gene leucine rich repeat containing 4B Neighboring gene Josephin domain containing 2 Neighboring gene transfer RNA alanine (anticodon AGC) 69

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC109059

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aspartate dehydrogenase domain-containing protein
    Names
    putative L-aspartate dehydrogenase
    NP_001009643.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009643.2 → NP_001009643.2  aspartate dehydrogenase domain-containing protein

      See identical proteins and their annotated locations for NP_001009643.2

      Status: PROVISIONAL

      Source sequence(s)
      AW435096, BC088252
      UniProtKB/TrEMBL
      A0A8L2QVB9, A6JAP1
      Conserved Domains (2) summary
      pfam03447
      Location:17 → 127
      NAD_binding_3; Homoserine dehydrogenase, NAD binding domain
      pfam01958
      Location:176 → 265
      DUF108; Domain of unknown function DUF108

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104094983..104097244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0J9.1 GenPept UniProtKB/Swiss-Prot:Q5I0J9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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