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    Gps2 G protein pathway suppressor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497941, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gps2provided by RGD
    Official Full Name
    G protein pathway suppressor 2provided by RGD
    Primary source
    RGD:1562746
    See related
    EnsemblRapid:ENSRNOG00000016360 AllianceGenome:RGD:1562746
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of protein K63-linked ubiquitination; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be part of transcription repressor complex. Orthologous to human GPS2 (G protein pathway suppressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 272.6), Kidney (RPKM 233.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gps2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55136043..55139106)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54637360..54640542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56524327..56527447)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2 like 1 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box binding protein 2 Neighboring gene solute carrier family 2 member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2. Guo C, et al. J Biol Chem, 2015 Feb 6. PMID 25519902, Free PMC Article
    2. GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARγ. Cardamone MD, et al. Cell Rep, 2014 Jul 10. PMID 24953653, Free PMC Article
    3. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Cardamone MD, et al. Mol Cell, 2018 Mar 1. PMID 29499132, Free PMC Article
    4. G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. Cheng X, et al. J Biol Chem, 2009 Dec 25. PMID 19858209, Free PMC Article
    5. A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Cardamone MD, et al. Mol Cell, 2012 Apr 13. PMID 22424771, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to mitochondrial depolarisation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein pathway suppressor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017477.1 → NP_001017477.1  G protein pathway suppressor 2

      See identical proteins and their annotated locations for NP_001017477.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083699
      UniProtKB/TrEMBL
      F7EYK5, Q5XII2
      Conserved Domains (2) summary
      pfam13863
      Location:41 → 89
      DUF4200; Domain of unknown function (DUF4200)
      pfam15991
      Location:5 → 292
      G_path_suppress; G-protein pathway suppressor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55136043..55139106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246785.4 → XP_006246847.1  G protein pathway suppressor 2 isoform X2

      See identical proteins and their annotated locations for XP_006246847.1

      UniProtKB/TrEMBL
      F7EYK5, Q5XII2
      Related
      ENSRNOP00000022041.4, ENSRNOT00000022041.6
      Conserved Domains (2) summary
      pfam13863
      Location:41 → 89
      DUF4200; Domain of unknown function (DUF4200)
      pfam15991
      Location:5 → 292
      G_path_suppress; G-protein pathway suppressor

    2. XM_039086596.2 → XP_038942524.1  G protein pathway suppressor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLY5
      Conserved Domains (1) summary
      pfam15991
      Location:5 → 292
      G_path_suppress; G-protein pathway suppressor

    3. XM_006246783.5 → XP_006246845.1  G protein pathway suppressor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLY5
      Related
      ENSRNOP00000097189.1, ENSRNOT00000110738.2
      Conserved Domains (1) summary
      pfam15991
      Location:5 → 292
      G_path_suppress; G-protein pathway suppressor
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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