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    Gstcd glutathione S-transferase, C-terminal domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310855, updated on 9-Dec-2024

    Summary

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    Symbol
    Gstcdprovided by RGD
    Full Name
    glutathione S-transferase, C-terminal domain containingprovided by RGD
    Primary source
    RGD:1311822
    See related
    EnsemblRapid:ENSRNOG00000011669 AllianceGenome:RGD:1311822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311822
    Summary
    Predicted to be active in cytoplasm. Orthologous to human GSTCD (glutathione S-transferase C-terminal domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 42.9), Thymus (RPKM 30.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gstcd in Genome Data Viewer
    Location:
    2q43
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (224173764..224268743, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221499732..221591888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (238109758..238253326, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nephronectin Neighboring gene MTOR associated protein, eak-7 homolog, pseudogene 1 Neighboring gene uncharacterized LOC102548236 Neighboring gene integrator complex subunit 12 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene uncharacterized LOC102546359 Neighboring gene inorganic pyrophosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GSTCD and INTS12 regulation and expression in the human lung. Obeidat M, et al. PLoS One, 2013. PMID 24058608, Free PMC Article
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase C-terminal domain-containing protein
    Names
    glutathione S-transferase C-terminal domain-containing protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395011.1 → NP_001381940.1  glutathione S-transferase C-terminal domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
      Related
      ENSRNOP00000088663.2, ENSRNOT00000107379.2
      Conserved Domains (2) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:420 → 538
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001395012.1 → NP_001381941.1  glutathione S-transferase C-terminal domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
      Conserved Domains (2) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:420 → 538
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001395013.1 → NP_001381942.1  glutathione S-transferase C-terminal domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
      Conserved Domains (2) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:420 → 538
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      224173764..224268743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281959.1 → XP_063138029.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3

    2. XM_039102457.2 → XP_038958385.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2K635, A6HVU3, D4A322, D4AC90
      Conserved Domains (2) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:420 → 538
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_063281960.1 → XP_063138030.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2K635, A6HVU3, D4A322, D4AC90
      Related
      ENSRNOP00000035041.4, ENSRNOT00000037154.6

    4. XM_063281958.1 → XP_063138028.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3

    5. XM_039102454.2 → XP_038958382.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
      Conserved Domains (2) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:420 → 538
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_063281962.1 → XP_063138032.1  glutathione S-transferase C-terminal domain-containing protein isoform X7

    7. XM_039102461.2 → XP_038958389.1  glutathione S-transferase C-terminal domain-containing protein isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:161 → 279
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    8. XM_039102458.2 → XP_038958386.1  glutathione S-transferase C-terminal domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A0G2K635, A6HVU3
      Conserved Domains (2) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:420 → 538
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    9. XM_039102460.2 → XP_038958388.1  glutathione S-transferase C-terminal domain-containing protein isoform X5

      UniProtKB/TrEMBL
      A6HVU4
      Conserved Domains (1) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    10. XM_039102459.2 → XP_038958387.1  glutathione S-transferase C-terminal domain-containing protein isoform X4

      UniProtKB/TrEMBL
      A6HVU4
      Conserved Domains (1) summary
      cl02776
      Location:235 → 326
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107725.1: Suppressed sequence

      Description
      NM_001107725.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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