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    Sorcs1 sortilin-related VPS10 domain containing receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309533, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sorcs1provided by RGD
    Official Full Name
    sortilin-related VPS10 domain containing receptor 1provided by RGD
    Primary source
    RGD:1305910
    See related
    EnsemblRapid:ENSRNOG00000011313 AllianceGenome:RGD:1305910
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in Golgi apparatus and membrane. Used to study proteinuria. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 68.6), Kidney (RPKM 23.3) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sorcs1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (259022007..259535731, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (249080662..249594520, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (269965824..270473097, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554215 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 4 Neighboring gene uncharacterized LOC134485246 Neighboring gene uncharacterized LOC120097667 Neighboring gene uncharacterized LOC102554335 Neighboring gene uncharacterized LOC134485247 Neighboring gene large ribosomal subunit protein eL29-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    is_active_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    VPS10 domain-containing receptor SorCS1
    Names
    VPS10 domain receptor protein SORCS 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191563.1 → NP_001178492.1  VPS10 domain-containing receptor SorCS1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LUZ4
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      259022007..259535731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231521.5 → XP_006231583.1  VPS10 domain-containing receptor SorCS1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLQ5
      Related
      ENSRNOP00000078816.1, ENSRNOT00000108738.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
    2. XM_006231519.5 → XP_006231581.1  VPS10 domain-containing receptor SorCS1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEA1
      Related
      ENSRNOP00000091270.2, ENSRNOT00000098704.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
    3. XM_006231520.5 → XP_006231582.1  VPS10 domain-containing receptor SorCS1 isoform X2

      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
    4. XM_006231525.4 → XP_006231587.1  VPS10 domain-containing receptor SorCS1 isoform X7

      Related
      ENSRNOP00000090827.2, ENSRNOT00000099121.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
    5. XM_039080712.2 → XP_038936640.1  VPS10 domain-containing receptor SorCS1 isoform X6

      Conserved Domains (2) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
    6. XM_006231523.5 → XP_006231585.1  VPS10 domain-containing receptor SorCS1 isoform X5

      Related
      ENSRNOP00000015979.4, ENSRNOT00000015979.6
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
    7. XM_063265314.1 → XP_063121384.1  VPS10 domain-containing receptor SorCS1 isoform X11

    8. XM_039080717.2 → XP_038936645.1  VPS10 domain-containing receptor SorCS1 isoform X8

      UniProtKB/TrEMBL
      A6JHS6
      Conserved Domains (2) summary
      smart00602
      Location:20 → 617
      VPS10; VPS10 domain
      pfam00801
      Location:631 → 704
      PKD; PKD domain
    9. XM_039080727.1 → XP_038936655.1  VPS10 domain-containing receptor SorCS1 isoform X10

      Conserved Domains (2) summary
      smart00602
      Location:1 → 316
      VPS10; VPS10 domain
      pfam00801
      Location:330 → 403
      PKD; PKD domain
    10. XM_039080722.2 → XP_038936650.1  VPS10 domain-containing receptor SorCS1 isoform X9

      Conserved Domains (2) summary
      smart00602
      Location:26 → 348
      VPS10; VPS10 domain
      pfam00801
      Location:362 → 435
      PKD; PKD domain
    11. XM_006231522.5 → XP_006231584.1  VPS10 domain-containing receptor SorCS1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AF53
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
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