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    Zbtb10 zinc finger and BTB domain containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80338, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zbtb10provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 10provided by RGD
    Primary source
    RGD:708377
    See related
    EnsemblRapid:ENSRNOG00000061862 AllianceGenome:RGD:708377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rinzf; ania-11
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZBTB10 (zinc finger and BTB domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 77.6), Heart (RPKM 70.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Zbtb10 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (94382670..94417308, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (92475254..92509892, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (94692939..94730976, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485606 Neighboring gene uncharacterized LOC120100770 Neighboring gene zinc finger protein 704 Neighboring gene uncharacterized LOC120100771 Neighboring gene high mobility group protein B1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 10
    Names
    zinc finger protein RIN ZF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024489.2NP_077815.2  zinc finger and BTB domain-containing protein 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K3H8, A6IH61
      Related
      ENSRNOP00000072643.2, ENSRNOT00000087598.3
      Conserved Domains (5) summary
      smart00597
      Location:240307
      ZnF_TTF; zinc finger in transposases and transcription factors
      sd00017
      Location:745765
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:363484
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam13465
      Location:758782
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:743767
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      94382670..94417308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103200.2XP_038959128.1  zinc finger and BTB domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY41, A6IH61
      Related
      ENSRNOP00000070510.2, ENSRNOT00000081553.3
      Conserved Domains (5) summary
      smart00597
      Location:240307
      ZnF_TTF; zinc finger in transposases and transcription factors
      sd00017
      Location:716736
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:334455
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam13465
      Location:729753
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:714738
      zf-H2C2_5; C2H2-type zinc-finger domain
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