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    Hsf2bp heat shock transcription factor 2 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499413, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsf2bpprovided by RGD
    Official Full Name
    heat shock transcription factor 2 binding proteinprovided by RGD
    Primary source
    RGD:1565879
    See related
    EnsemblRapid:ENSRNOG00000001193 AllianceGenome:RGD:1565879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565879
    Summary
    Predicted to be involved in meiosis I and spermatogenesis. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 19. Orthologous to human HSF2BP (heat shock transcription factor 2 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 23.1), Kidney (RPKM 5.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsf2bp in Genome Data Viewer
    Location:
    20p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10035263..10121262, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10035562..10123059, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10757172..10844177, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483883 Neighboring gene uncharacterized LOC120098852 Neighboring gene ribosomal RNA processing 1B Neighboring gene pyridoxal kinase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in double-strand break repair involved in meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heat shock factor 2-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127683.1 → NP_001121155.1  heat shock factor 2-binding protein

      See identical proteins and their annotated locations for NP_001121155.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JK16, G3V646
      Related
      ENSRNOP00000110974.1, ENSRNOT00000149910.1
      Conserved Domains (1) summary
      cl19764
      Location:50 → 119
      COG6; Conserved oligomeric complex COG6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10035263..10121262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099004.2 → XP_038954932.1  heat shock factor 2-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1G2
      Related
      ENSRNOP00000071827.2, ENSRNOT00000079207.3
      Conserved Domains (1) summary
      COG1196
      Location:15 → 150
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039099002.2 → XP_038954930.1  heat shock factor 2-binding protein isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:15 → 150
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_063279457.1 → XP_063135527.1  heat shock factor 2-binding protein isoform X3

      UniProtKB/TrEMBL
      B0BNC3
    Nucleotide Protein Strain
    Heading Accession and Version

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