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    Hcfc2 host cell factor C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314704, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hcfc2provided by RGD
    Official Full Name
    host cell factor C2provided by RGD
    Primary source
    RGD:1307385
    See related
    EnsemblRapid:ENSRNOG00000053510 AllianceGenome:RGD:1307385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear body; and plasma membrane. Predicted to be part of MLL1 complex and Set1C/COMPASS complex. Orthologous to human HCFC2 (host cell factor C2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 138.8), Heart (RPKM 114.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hcfc2 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22875440..22907391, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20983986..21019826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (27107931..27136658, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692815 Neighboring gene nuclear transcription factor Y subunit beta Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene thymine-DNA glycosylase Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC95223

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity  
    enables transcription coregulator activity  
    enables transcription coregulator activity  
    Component Evidence Code Pubs
    part_of MLL1 complex  
    part_of MLL1 complex  
    part_of MLL1/2 complex  
    part_of Set1C/COMPASS complex  
    part_of Set1C/COMPASS complex  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    part_of histone methyltransferase complex  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    host cell factor 2
    Names
    C2 factor
    HCF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008357.1NP_001008358.1  host cell factor 2

      See identical proteins and their annotated locations for NP_001008358.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085951
      UniProtKB/Swiss-Prot
      Q5RKG2
      UniProtKB/TrEMBL
      A0A0G2JXF9, A6IFI3
      Related
      ENSRNOP00000070255.2, ENSRNOT00000086905.3
      Conserved Domains (6) summary
      PLN02193
      Location:2262
      PLN02193; nitrile-specifier protein
      cd00063
      Location:549603
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:190241
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:2259
      Kelch_1; Kelch motif
      pfam13415
      Location:207253
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:312354
      Kelch_5; Kelch motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22875440..22907391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079037.2XP_038934965.1  host cell factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXF9, A0A8I5Y755
      Related
      ENSRNOP00000104880.1, ENSRNOT00000147485.1
      Conserved Domains (2) summary
      PLN02193
      Location:2262
      PLN02193; nitrile-specifier protein
      sd00038
      Location:190241
      Kelch; KELCH repeat [structural motif]
    2. XM_039079039.2XP_038934967.1  host cell factor 2 isoform X2

      Conserved Domains (2) summary
      PLN02193
      Location:2262
      PLN02193; nitrile-specifier protein
      sd00038
      Location:190241
      Kelch; KELCH repeat [structural motif]

    RNA

    1. XR_005486622.2 RNA Sequence

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