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    Gcsam germinal center-associated, signaling and motility [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gcsamprovided by RGD
    Official Full Name
    germinal center-associated, signaling and motilityprovided by RGD
    Primary source
    RGD:1591321
    See related
    EnsemblRapid:ENSRNOG00000022110 AllianceGenome:RGD:1591321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcet2
    Summary
    Predicted to enable actin binding activity; myosin II binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of lymphocyte migration and regulation of B cell receptor signaling pathway. Orthologous to human GCSAM (germinal center associated signaling and motility). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 97.8), Thymus (RPKM 81.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gcsam in Genome Data Viewer
    Location:
    11q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68658350..68669598, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55195757..55207011, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60168938..60180191, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 7 Neighboring gene similar to human chromosome 3 open reading frame 52 Neighboring gene solute carrier family 9 member C1 Neighboring gene Tnf receptor associated factor 4, pseudogene 1 Neighboring gene CD200 molecule like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Romero-Camarero I, et al. Nat Commun, 2013. PMID 23299888, Free PMC Article
    2. HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. Lu X, et al. Blood, 2007 Dec 15. PMID 17823310, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin II binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of lymphocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    germinal center expressed transcript 2; germinal center-associated signaling and motility protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432441.1 → NP_001419370.1  germinal center expressed transcript 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      D3ZLK1

    2. NM_001432442.1 → NP_001419371.1  germinal center expressed transcript 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A1W2Q6E0, A6IQY4

    3. NM_001432443.1 → NP_001419372.1  germinal center expressed transcript 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      68658350..68669598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248351.5 → XP_006248413.1  germinal center-associated signaling and motility protein isoform X2

      Related
      ENSRNOP00000076218.1, ENSRNOT00000093731.3
      Conserved Domains (1) summary
      pfam15666
      Location:52 → 133
      HGAL; Germinal center-associated lymphoma

    2. XM_001064866.7 → XP_001064866.2  germinal center-associated signaling and motility protein isoform X1

      Related
      ENSRNOP00000041206.1, ENSRNOT00000043020.5
      Conserved Domains (1) summary
      pfam15666
      Location:75 → 156
      HGAL; Germinal center-associated lymphoma

    3. XM_039088890.2 → XP_038944818.1  germinal center-associated signaling and motility protein isoform X3

      Conserved Domains (1) summary
      pfam15666
      Location:28 → 115
      HGAL; Germinal center-associated lymphoma
    Nucleotide Protein Strain
    Heading Accession and Version

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