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    Arhgap26 Rho GTPase activating protein 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap26provided by RGD
    Official Full Name
    Rho GTPase activating protein 26provided by RGD
    Primary source
    RGD:1310923
    See related
    EnsemblRapid:ENSRNOG00000013920 AllianceGenome:RGD:1310923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in mitophagy. Predicted to be located in cytosol and endosome membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 99.0), Heart (RPKM 96.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap26 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30702602..31489047)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (30835806..31237945)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31807052..32557176, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098127 Neighboring gene uncharacterized LOC134482935 Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene small ribosomal subunit protein uS5-like Neighboring gene uncharacterized LOC120098315 Neighboring gene fibroblast growth factor 1 Neighboring gene Cytochrome c oxidase subunit 7C, pseudogene 2 Neighboring gene uncharacterized LOC134482937 Neighboring gene uncharacterized LOC120098335 Neighboring gene uncharacterized LOC134482936 Neighboring gene uncharacterized LOC100911367 Neighboring gene nuclear receptor subfamily 3, group C, member 1 Neighboring gene poly(A) binding protein, cytoplasmic 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Borkhardt A, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10908648, Free PMC Article
    2. A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. Eberth A, et al. Biochem J, 2009 Jan 1. PMID 18954304
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395140.1 → NP_001382069.1  rho GTPase-activating protein 26

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6AL79
      Related
      ENSRNOP00000094639.1, ENSRNOT00000106545.2
      Conserved Domains (4) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:704 → 759
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      30702602..31489047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277362.1 → XP_063133432.1  rho GTPase-activating protein 26 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLR1

    2. XM_006254660.5 → XP_006254722.1  rho GTPase-activating protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AL79, A0A8I6APL5
      Related
      ENSRNOP00000096429.1, ENSRNOT00000101992.2
      Conserved Domains (5) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:759 → 814
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 364
      PH; PH domain

    3. XM_006254663.4 → XP_006254725.1  rho GTPase-activating protein 26 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLR1, A0A8I6AAB3
      Related
      ENSRNOP00000090557.1, ENSRNOT00000115900.2
      Conserved Domains (5) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:667 → 722
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 364
      PH; PH domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107389.1: Suppressed sequence

      Description
      NM_001107389.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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