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    Wdr47 WD repeat domain 47 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310785, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr47provided by RGD
    Official Full Name
    WD repeat domain 47provided by RGD
    Primary source
    RGD:1309181
    See related
    EnsemblRapid:ENSRNOG00000020330 AllianceGenome:RGD:1309181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309181
    Summary
    Predicted to act upstream of or within several processes, including detection of hot stimulus involved in thermoception; neuronal stem cell population maintenance; and telencephalon development. Located in cytoplasm. Orthologous to human WDR47 (WD repeat domain 47). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 257.3), Testes (RPKM 79.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wdr47 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198914977..198975844)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196226757..196287739)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211380894..211441817)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 167B Neighboring gene TATA-box binding protein associated factor 13 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene chloride channel CLIC-like 1 Neighboring gene G-protein signaling modulator 2

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anterior commissure morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebral cortex radial glia-guided migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within corpus callosum development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within detection of hot stimulus involved in thermoception ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within motor behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 47

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100702.1NP_001094172.1  WD repeat-containing protein 47

      See identical proteins and their annotated locations for NP_001094172.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A8I5Y1M2, A6HV14, G3V9M3
      Conserved Domains (5) summary
      smart00667
      Location:942
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      COG2319
      Location:547920
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:601917
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:613661
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198914977..198975844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233155.5XP_006233217.1  WD repeat-containing protein 47 isoform X5

      See identical proteins and their annotated locations for XP_006233217.1

      UniProtKB/TrEMBL
      A0A8I5Y1M2
      Related
      ENSRNOP00000052715.3, ENSRNOT00000055862.4
      Conserved Domains (5) summary
      smart00667
      Location:942
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      COG2319
      Location:554927
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:608924
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:620668
      7WD40; WD40 repeat [structural motif]
    2. XM_063281931.1XP_063138001.1  WD repeat-containing protein 47 isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y1M2
    3. XM_063281928.1XP_063137998.1  WD repeat-containing protein 47 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y1M2
    4. XM_063281924.1XP_063137994.1  WD repeat-containing protein 47 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1M2
    5. XM_063281923.1XP_063137993.1  WD repeat-containing protein 47 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y1M2
    6. XM_063281926.1XP_063137996.1  WD repeat-containing protein 47 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y1M2
    7. XM_063281925.1XP_063137995.1  WD repeat-containing protein 47 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y1M2
    8. XM_063281927.1XP_063137997.1  WD repeat-containing protein 47 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y1M2
    9. XM_063281929.1XP_063137999.1  WD repeat-containing protein 47 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y1M2, A6HV14, G3V9M3
      Related
      ENSRNOP00000077485.2, ENSRNOT00000105849.2
    10. XM_063281930.1XP_063138000.1  WD repeat-containing protein 47 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y1M2