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    Naxe NAD(P)HX epimerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295229, updated on 9-Dec-2024

    Summary

    Official Symbol
    Naxeprovided by RGD
    Official Full Name
    NAD(P)HX epimeraseprovided by RGD
    Primary source
    RGD:1304699
    See related
    EnsemblRapid:ENSRNOG00000019201 AllianceGenome:RGD:1304699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AI-BP; Apoa1bp
    Summary
    Enables NAD(P)HX epimerase activity. Involved in metabolite repair. Predicted to be located in cell body; cilium; and extracellular space. Orthologous to human NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 164.4), Heart (RPKM 163.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Naxe in Genome Data Viewer
    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175816824..175818903, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173518971..173521036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187424319..187426410, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene G patch domain containing 4 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene IQ motif containing GTPase activating protein 3

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD(P)HX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD(P)HX epimerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane raft distribution ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane raft distribution ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metabolite repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nicotinamide nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NAD(P)H-hydrate epimerase
    Names
    apolipoprotein A-I-binding protein
    NP_001386156.1
    XP_063137676.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399227.1NP_001386156.1  NAD(P)H-hydrate epimerase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      B0BNM1
      Related
      ENSRNOP00000025986.2, ENSRNOT00000025986.5
      Conserved Domains (1) summary
      PLN03049
      Location:50281
      PLN03049; pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175816824..175818903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281606.1XP_063137676.1  NAD(P)H-hydrate epimerase isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106440.1: Suppressed sequence

      Description
      NM_001106440.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.