Mmp14 matrix metallopeptidase 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mmp14provided by RGD
Official Full Name: matrix metallopeptidase 14provided by RGD
Primary source: RGD:620198
See related: EnsemblRapid:ENSRNOG00000010947 AllianceGenome:RGD:620198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mt1-mmp
Summary: Enables integrin binding activity. Involved in several processes, including gonad development; negative regulation of focal adhesion assembly; and response to odorant. Predicted to be located in several cellular components, including cytosol; intermediate filament cytoskeleton; and macropinosome. Predicted to be active in extracellular space and plasma membrane. Used to study ischemia. Biomarker of IgA glomerulonephritis; anti-basement membrane glomerulonephritis; artery disease (multiple); cerebrovascular disease (multiple); and congestive heart failure. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 594.1), Adrenal (RPKM 380.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (31857824..31867049)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (27887795..27897020)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33074441..33083666)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.
Title: Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.
Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-kappaB signaling pathway.
Title: Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-κB signaling pathway.
our results suggest that mechanical stretching inhibits bone-marrow-derived mesenchymal stem cells invasion by downregulating MT1-MMP expression by suppressing the PI3K/Akt signaling pathway.
Title: MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells.
Evidence shows that MT1-MMP take action in the beginning of vascular matrix dissolution, endothelial cell growth, vascular remodeling and ultimately in angiogenesis.
Title: Effects of treadmill exercise on cerebral angiogenesis and MT1-MMP expression after cerebral ischemia in rats.
The results suggest that MMP-14 is involved in proliferative diabetic retinopathy angiogenesis.
Title: Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy.
expression of MMP-14 was different between cardiac isografts and allografts. MMP-14 could interact with CD44 in allografts.
Title: MMP-14 promotes VSMC migration via up-regulating CD44 expression in cardiac allograft vasculopathy.
that MT1-MMP contributes to intestinal development, particularly to villi morphogenesis
Title: MT1-MMP and its potential role in the vertebrate intestinal morphogenesis.
Downregulation of miR-193a-3p promoted loss of type II collagen by directly targeting MMP14 in IDD. miR-193a-3p inhibited IDD in vitro and in vivo. miR-193a-3p may be a promising candidate for prevention of degenerative disc disease.
Title: Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.
the endothelium under ANGII stimulation acts as a novel and key activator of latent pro-MT1MMP and pro-MMP2 in smooth muscle cells of rat aorta
Title: A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta.
Heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGFR transactivation.
Title: Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation.

Submit: New GeneRIF Correction See all GeneRIFs (44)

General gene information

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Markers

Mmp14 (e-PCR), detects polymorphism
- UniSTS:143879

BI286324 (e-PCR)
- UniSTS:245307

Mmp14 (e-PCR), detects polymorphism
- UniSTS:527424

AI325305 (e-PCR)
- UniSTS:180651

MARC_9867-9868:996688667:1 (e-PCR)
- UniSTS:270019

RH91125 (e-PCR)
- UniSTS:88304

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables metalloaminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in astrocyte cell migration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within head development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of GDF15-GFRAL signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in tissue remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zymogen activation	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in macropinosome	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: matrix metalloproteinase-14

Names: MMP-14; MT-MMP 1; MT1MMP; MTMMP1; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; membrane type 1-matrix metalloproteinase; membrane-type matrix metalloproteinase 1

NP_112318.1

EC 3.4.24.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031056.1 → NP_112318.1 matrix metalloproteinase-14 precursor

See identical proteins and their annotated locations for NP_112318.1

Status: PROVISIONAL

Source sequence(s)

X91785

UniProtKB/Swiss-Prot

Q10739, Q6IN06

UniProtKB/TrEMBL

A0A8I5ZRB7, A6KGU1

Related

ENSRNOP00000065434.1, ENSRNOT00000075610.4

Conserved Domains (4) summary

cd00094
Location:316 → 508

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:118 → 284

Peptidase_M10; Matrixin

pfam01471
Location:36 → 88

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:560 → 582

DUF3377; Domain of unknown function (DUF3377)