Ppy pancreatic polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppyprovided by RGD
Official Full Name: pancreatic polypeptideprovided by RGD
Primary source: RGD:3385
See related: EnsemblRapid:ENSRNOG00000020874 AllianceGenome:RGD:3385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable neuropeptide Y receptor binding activity and neuropeptide hormone activity. Predicted to be involved in feeding behavior and neuropeptide signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human PPY (pancreatic polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 2.7), Lung (RPKM 2.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87554941..87556236, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87054747..87056044, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90041582..90043316, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pancreas-projecting rat dorsal motor nucleus of the vagus neurons are heterogeneous with respect to their response to PP, which may underlie functional differences in the vagal modulation of pancreatic functions
Title: Effects of pancreatic polypeptide on pancreas-projecting rat dorsal motor nucleus of the vagus neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94822 (e-PCR)
- UniSTS:120068

D10Arb15 (e-PCR)
- UniSTS:239679

D10Hmgc2 (e-PCR)
- UniSTS:261704

D10Wox17 (e-PCR)
- UniSTS:118117

D11Kyo1 (e-PCR), detects polymorphism
- UniSTS:118117

Ppy (e-PCR), detects polymorphism
- UniSTS:256692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pancreatic polypeptide prohormone

Names: PP; pancreatic prohormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.