Brinp1 BMP/retinoic acid inducible neural specific 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brinp1provided by RGD
Official Full Name: BMP/retinoic acid inducible neural specific 1provided by RGD
Primary source: RGD:708519
See related: EnsemblRapid:ENSRNOG00000005561 AllianceGenome:RGD:708519
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dbc1; Dbccr1
Summary: Predicted to be involved in cellular response to retinoic acid; central nervous system development; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within several processes, including behavioral fear response; maternal behavior; and protein stabilization. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and neuronal cell body. Orthologous to human BRINP1 (BMP/retinoic acid inducible neural specific 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 243.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (87363621..87565580, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (82348501..82550506, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (84919416..85123828, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings of this study identify a role for RLR signaling and type I IFN in regulating astrocyte innate immune responses after SCI. (c) 2011 Wiley Periodicals, Inc.
Title: Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Rat147 (e-PCR), detects polymorphism
- UniSTS:227870

D5Got22 (e-PCR)
- UniSTS:112158

BE118680 (e-PCR)
- UniSTS:248866

BE120599 (e-PCR)
- UniSTS:247367

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in behavioral fear response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in exploration behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in maternal behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maternal behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in short-term memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within short-term memory	ISO Inferred from Sequence Orthology more info
involved_in social behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BMP/retinoic acid-inducible neural-specific protein 1

Names: bone morphogenetic protein/retinoic acid inducible neural-specific 1; bone morphogenic protein/retinoic acid inducible neural-specific 1; deleted in bladder cancer 1; deleted in bladder cancer chromosome region candidate 1; deleted in bladder cancer protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080482.3 → NP_536730.2 BMP/retinoic acid-inducible neural-specific protein 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q925T8

UniProtKB/TrEMBL

A6J803, G3V6Q9

Related

ENSRNOP00000007578.2, ENSRNOT00000007578.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

87363621..87565580 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238272.5 → XP_006238334.1 BMP/retinoic acid-inducible neural-specific protein 1 isoform X1

Conserved Domains (2) summary

smart00457
Location:73 → 251

MACPF; membrane-attack complex / perforin

pfam19052
Location:306 → 760

BRINP; BMP/retinoic acid-inducible neural-specific protein