Slc2a13 solute carrier family 2 member 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a13provided by RGD
Official Full Name: solute carrier family 2 member 13provided by RGD
Primary source: RGD:621814
See related: EnsemblRapid:ENSRNOG00000015741 AllianceGenome:RGD:621814
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hmit
Summary: Enables myo-inositol transmembrane transporter activity. Involved in myo-inositol transport. Located in several cellular components, including astrocyte end-foot; cell body; and growth cone. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 110.9), Kidney (RPKM 85.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (124278881..124606146, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (122399329..122726605, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (132430852..132757558, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that H(+)/myo-inositol cotransporter (HMIT) is expressed in marginal cells and basal cells of the stria vascularis, while Na(+)/myo-inositol cotransporter 1 (SMIT1) expression is enriched in basal cells. Study speculates that HMIT and SMIT1 may play important roles in the homeostasis of cochlear fluids.
Title: Differential localizations of the myo-inositol transporters HMIT and SMIT1 in the cochlear stria vascularis.
HMIT is primarily a neuronal transporter widely expressed in the rat and human brain, with particularly high levels in the hippocampus and cortex, as shown by immunohistochemistry.
Title: Evaluation of expression and function of the H+/myo-inositol transporter HMIT.
HMIT is expressed in a vesicular compartment involved in activity-dependent regulation of myo-inositol uptake in neurons
Title: Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables myo-inositol transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables myo-inositol:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables myo-inositol:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in myo-inositol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in myo-inositol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in myo-inositol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in astrocyte end-foot	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
NOT located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
NOT located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
NOT located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
NOT located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proton myo-inositol cotransporter

Names: h(+)-myo-inositol cotransporter; h(+)-myo-inositol symporter; proton myo-inositol symporter; solute carrier family 2 (facilitated glucose transporter), member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133611.2 → NP_598295.2 proton myo-inositol cotransporter

See identical proteins and their annotated locations for NP_598295.2

Status: VALIDATED

Source sequence(s)

AJ315643, FQ117644, JAXUCZ010000007

UniProtKB/Swiss-Prot

Q921A2

Related

ENSRNOP00000021153.2, ENSRNOT00000021153.5

Conserved Domains (2) summary

cd06174
Location:75 → 580

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:78 → 598

Sugar_tr; Sugar (and other) transporter