Birc3 baculoviral IAP repeat-containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Birc3provided by RGD
Official Full Name: baculoviral IAP repeat-containing 3provided by RGD
Primary source: RGD:621282
See related: EnsemblRapid:ENSRNOG00000005731 AllianceGenome:RGD:621282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IAP1; Birc2
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in spermatogenesis. Part of protein-containing complex. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus adenocarcinoma; extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 146.7), Thymus (RPKM 76.0) and 8 other tissues See more
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Genomic context

Location:: 8q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (13285702..13313329, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (5000844..5028470, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (6048590..6076828, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The overexpression of pro-survival XIAP and IAP-1 in the retinas was not associated with similar changes in the optic nerves of glaucomatous eyes. This may explain the increased vulnerability of optic nerves to elevated intraocular pressure.
Title: Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma.
Tnfrsf1a, Birc2 and Birc3 of Schwann cells, not originally regarded as XIAP, were mainly responsible for the inflammation-mediated anti-apoptosis of peripheral nerves.
Title: Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves.
Baculoviral IAP1 underlies ischemic preconditioning-induced protection in neurons and vascular endothelial cells against hypoxia-ischemia in rat neonatal brain.
Title: Ischemic preconditioning reduces neurovascular damage after hypoxia-ischemia via the cellular inhibitor of apoptosis 1 in neonatal brain.
Flt-1 expression influences apoptotic susceptibility of vascular smooth muscle cells through the NF-kappaB/IAP-1 pathway.
Title: Flt-1 expression influences apoptotic susceptibility of vascular smooth muscle cells through the NF-kappaB/IAP-1 pathway.
expression of IAP1 & IAP2 show different cycles throughout the seminiferous epithelial cycle of the testis; the cellular distribution of these proteins is also different; results illustrate the role IAPs play in the regulation of spermatogenic apoptosis
Title: The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis.
decrease in IAP-1 expression by TGF-beta1 might provide an important regulatory function in TGF-beta1-mediated microglial death and in attenuation of excessive microglial activation in pathological conditions.
Title: Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia.
It is reported report that ras oncogene, an established inhibitor of anoikis, triggers a significant upregulation of anti-apoptotic proteins cIAP2 and XIAP in intestinal epithelial cells.
Title: ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:236051 (e-PCR)
- UniSTS:236051

RH139096 (e-PCR)
- UniSTS:221182

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 3

Names: inhibitor of apoptosis protein 1

NP_076477.3

EC 2.3.2.27

XP_006242561.1

EC 2.3.2.27

XP_006242562.1

EC 2.3.2.27

XP_006242564.1

EC 2.3.2.27

XP_006242565.1

EC 2.3.2.27

XP_038938121.1

EC 2.3.2.27

XP_063122270.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023987.3 → NP_076477.3 baculoviral IAP repeat-containing protein 3

See identical proteins and their annotated locations for NP_076477.3

Status: VALIDATED

Source sequence(s)

BC083555, CA505609

UniProtKB/TrEMBL

A0A0G2JTI9, Q9ESE9

Conserved Domains (6) summary

smart00238
Location:290 → 358

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:206 → 272

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:412 → 461

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:585 → 638

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

pfam00653
Location:68 → 133

BIR; Inhibitor of Apoptosis domain

cl14633
Location:476 → 564

DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

13285702..13313329 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242503.5 → XP_006242565.1 baculoviral IAP repeat-containing protein 3 isoform X2

See identical proteins and their annotated locations for XP_006242565.1

UniProtKB/TrEMBL

Q5XIW4, Q9ESE9

Conserved Domains (5) summary

smart00238
Location:254 → 322

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:170 → 236

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

pfam13920
Location:551 → 596

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl14633
Location:440 → 528

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006242502.5 → XP_006242564.1 baculoviral IAP repeat-containing protein 3 isoform X2

See identical proteins and their annotated locations for XP_006242564.1

UniProtKB/TrEMBL

Q5XIW4, Q9ESE9

Conserved Domains (5) summary

smart00238
Location:254 → 322

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:170 → 236

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

pfam13920
Location:551 → 596

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl14633
Location:440 → 528

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063266200.1 → XP_063122270.1 baculoviral IAP repeat-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JTI9, Q9ESE9
XM_006242500.4 → XP_006242562.1 baculoviral IAP repeat-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006242562.1

UniProtKB/TrEMBL

A0A0G2JTI9, Q9ESE9

Conserved Domains (6) summary

smart00238
Location:290 → 358

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:206 → 272

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:412 → 461

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:585 → 638

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

pfam00653
Location:68 → 133

BIR; Inhibitor of Apoptosis domain

cl14633
Location:476 → 564

DD; Death Domain Superfamily of protein-protein interaction domains
XM_039082193.2 → XP_038938121.1 baculoviral IAP repeat-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JTI9, Q9ESE9

Conserved Domains (6) summary

smart00238
Location:290 → 358

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:206 → 272

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:412 → 461

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:585 → 638

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

pfam00653
Location:68 → 133

BIR; Inhibitor of Apoptosis domain

cl14633
Location:476 → 564

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006242499.4 → XP_006242561.1 baculoviral IAP repeat-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006242561.1

UniProtKB/TrEMBL

A0A0G2JTI9, Q9ESE9

Related

ENSRNOP00000068729.2, ENSRNOT00000090774.3

Conserved Domains (6) summary

smart00238
Location:290 → 358

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:206 → 272

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:412 → 461

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:585 → 638

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

pfam00653
Location:68 → 133

BIR; Inhibitor of Apoptosis domain

cl14633
Location:476 → 564

DD; Death Domain Superfamily of protein-protein interaction domains