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    Sf3b6 splicing factor 3B, subunit 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100365504, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sf3b6provided by RGD
    Official Full Name
    splicing factor 3B, subunit 6provided by RGD
    Primary source
    RGD:2318878
    See related
    EnsemblRapid:ENSRNOG00000046172 AllianceGenome:RGD:2318878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of U2 snRNP and spliceosomal complex. Orthologous to human SF3B6 (splicing factor 3b subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 271.5), Kidney (RPKM 198.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sf3b6 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33545495..33554537)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27826044..27835086)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (29991232..29999668, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene profilin family, member 4 Neighboring gene tumor protein p53 inducible protein 3 Neighboring gene FKBP prolyl isomerase 1B Neighboring gene U6 spliceosomal RNA Neighboring gene WD repeat and coiled coil containing Neighboring gene MFSD2 lysolipid transporter B, sphingolipid

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    splicing factor 3B subunit 6
    Names
    splicing factor 3B, 14 kDa subunit-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271222.1NP_001258151.1  splicing factor 3B subunit 6

      See identical proteins and their annotated locations for NP_001258151.1

      Status: VALIDATED

      Source sequence(s)
      FM089942, FM108041, FM109760
      UniProtKB/TrEMBL
      A0A8I6AFT8, A6HAJ3, M0R835
      Related
      ENSRNOP00000091764.1, ENSRNOT00000110429.2
      Conserved Domains (1) summary
      cd12241
      Location:1793
      RRM_SF3B14; RNA recognition motif (RRM) found in pre-mRNA branch site protein p14 (SF3B14) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      33545495..33554537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)