Eml3 EMAP like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eml3provided by RGD
Official Full Name: EMAP like 3provided by RGD
Primary source: RGD:7630023
See related: EnsemblRapid:ENSRNOG00000019873 AllianceGenome:RGD:7630023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311368
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; mitotic metaphase chromosome alignment; and regulation of mitotic spindle assembly. Predicted to be located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. Predicted to colocalize with mitotic spindle. Orthologous to human EML3 (EMAP like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 112.7), Spleen (RPKM 102.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215255459..215266895)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205826354..205837790)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225128997..225140472)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic spindle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
colocalizes_with mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 3

Names: echinoderm microtubule associated protein like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401767.1 → NP_001388696.1 echinoderm microtubule-associated protein-like 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6HZX9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

215255459..215266895

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231007.5 → XP_006231069.1 echinoderm microtubule-associated protein-like 3 isoform X1

See identical proteins and their annotated locations for XP_006231069.1

UniProtKB/TrEMBL

A6HZX8, A6HZX9, D4A4R1

Related

ENSRNOP00000026938.5, ENSRNOT00000026938.8

Conserved Domains (4) summary

sd00039
Location:644 → 679

7WD40; WD40 repeat [structural motif]

pfam03451
Location:216 → 285

HELP; HELP motif

cd21949
Location:6 → 34

TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3

cl29593
Location:552 → 869

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006231009.5 → XP_006231071.1 echinoderm microtubule-associated protein-like 3 isoform X2

See identical proteins and their annotated locations for XP_006231071.1

UniProtKB/TrEMBL

A6HZX9

Related

ENSRNOP00000091580.2, ENSRNOT00000114659.2

Conserved Domains (4) summary

COG2319
Location:302 → 704

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:216 → 285

HELP; HELP motif

sd00039
Location:592 → 627

7WD40; WD40 repeat [structural motif]

cl02567
Location:500 → 817

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...