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    Kat14 lysine acetyltransferase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kat14provided by RGD
    Official Full Name
    lysine acetyltransferase 14provided by RGD
    Primary source
    RGD:1309538
    See related
    EnsemblRapid:ENSRNOG00000007160 AllianceGenome:RGD:1309538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Csrp2bp
    Summary
    Predicted to enable histone acetyltransferase activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of embryonic development; and regulation of tubulin deacetylation. Predicted to act upstream of or within G2/M transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of ATAC complex. Orthologous to human KAT14 (lysine acetyltransferase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 107.8), Thymus (RPKM 67.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kat14 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (152194560..152235048)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (131736430..131781732)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (138508899..138549437)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase 3, pseudogene 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene ovo-like zinc finger 2 Neighboring gene PET117 cytochrome c oxidase chaperone Neighboring gene uncharacterized LOC134486459 Neighboring gene zinc finger protein 133 Neighboring gene double zinc ribbon and ankyrin repeat domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). Weiskirchen R, et al. Biochem Biophys Res Commun, 2000 Aug 11. PMID 10924333
    2. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    3. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
    4. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
    5. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich protein 2-binding protein
    Names
    CSRP2 binding protein
    cysteine and glycine-rich protein 2 binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191855.1 → NP_001178784.1  cysteine-rich protein 2-binding protein

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K6P6, D3ZSX8
      Related
      ENSRNOP00000009437.5, ENSRNOT00000009437.8
      Conserved Domains (1) summary
      pfam00583
      Location:669 → 748
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      152194560..152235048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105474.2 → XP_038961402.1  cysteine-rich protein 2-binding protein isoform X1

      Conserved Domains (1) summary
      pfam00583
      Location:458 → 537
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein Strain
    Heading Accession and Version

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