Fzd4 frizzled class receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fzd4provided by RGD
Official Full Name: frizzled class receptor 4provided by RGD
Primary source: RGD:71017
See related: EnsemblRapid:ENSRNOG00000063590 AllianceGenome:RGD:71017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables Wnt-protein binding activity and signaling receptor activity. Involved in Wnt signaling pathway; positive regulation of dendrite morphogenesis; and positive regulation of neuron projection arborization. Predicted to be located in cell surface; cell-cell junction; and dendrite. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 178.9), Lung (RPKM 98.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (152692507..152701372)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (143279934..143288799)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (153589471..153598376)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-129-5p in exosomes inhibits diabetes-associated osteogenesis in the jaw via targeting FZD4.
Title: miR-129-5p in exosomes inhibits diabetes-associated osteogenesis in the jaw via targeting FZD4.
Study identified a novel Wnt5a/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis
Title: A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.
Activation of frizzled-4 receptor protected blood-brain barrier after subarachnoid hemorrhage.
Title: Norrin protected blood-brain barrier via frizzled-4/β-catenin pathway after subarachnoid hemorrhage in rats.
detected expression of a putative wnt receptor, frizzled-4 (fzd-4) in the ovary; analyses using both RT-PCR and ISH indicated that granulosa cells express fzd-4 mRNA
Title: Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130494 (e-PCR)
- UniSTS:213778

Fzd4 (e-PCR), detects polymorphism
- UniSTS:506910

Fzd4 (e-PCR), detects polymorphism
- UniSTS:516477

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Norrin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway, calcium modulating pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cerebellum vasculature morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within luteinization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection arborization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection arborization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within progesterone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina vasculature development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retina vasculature morphogenesis in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retina vasculature morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retinal blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: frizzled-4

Names: frizzled family receptor 4; frizzled receptor 4; fz-4; rFz4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022623.4 → NP_072145.1 frizzled-4 precursor

See identical proteins and their annotated locations for NP_072145.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9QZH0

UniProtKB/TrEMBL

A6I5Z8

Related

ENSRNOP00000088712.1, ENSRNOT00000106139.2

Conserved Domains (2) summary

cd07448
Location:43 → 168

CRD_FZ4; Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor

pfam01534
Location:211 → 510

Frizzled; Frizzled/Smoothened family membrane region