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    Mllt6 MLLT6, PHD finger containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mllt6provided by RGD
    Official Full Name
    MLLT6, PHD finger containingprovided by RGD
    Primary source
    RGD:1306689
    See related
    EnsemblRapid:ENSRNOG00000053285 AllianceGenome:RGD:1306689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Predicted to act upstream of or within several processes, including renal potassium excretion; renal sodium excretion; and renal water absorption. Orthologous to human MLLT6 (MLLT6, PHD finger containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 98.8), Kidney (RPKM 96.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mllt6 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83152317..83175264)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82657258..82678899)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85607988..85628171)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548331 Neighboring gene uncharacterized LOC134480715 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein Neighboring gene uncharacterized LOC120095289 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene polycomb group ring finger 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Af17 deficiency increases sodium excretion and decreases blood pressure. Chen L, et al. J Am Soc Nephrol, 2011 Jun. PMID 21546577, Free PMC Article
    2. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Chen S, et al. Mol Cell, 2015 Oct 15. PMID 26439302, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within renal potassium excretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within renal system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within renal water absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein AF-17
    Names
    MLLT6, PHD finger domain containing
    myeloid/lymphoid or mixed lineage-leukemia translocation to 6 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
    translocated to, 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427040.2 → NP_001413969.1  protein AF-17

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83152317..83175264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087724.2 → XP_038943652.1  protein AF-17 isoform X1

      Conserved Domains (3) summary
      cd15574
      Location:7 → 54
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15709
      Location:61 → 185
      ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
      cd20901
      Location:714 → 768
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    2. XM_063269120.1 → XP_063125190.1  protein AF-17 isoform X2

    3. XM_039087728.2 → XP_038943656.1  protein AF-17 isoform X5

      UniProtKB/TrEMBL
      A6HIL2
      Conserved Domains (2) summary
      cd15574
      Location:7 → 54
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15709
      Location:61 → 185
      ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins

    4. XM_063269119.1 → XP_063125189.1  protein AF-17 isoform X1

    5. XM_039087726.2 → XP_038943654.1  protein AF-17 isoform X4

      Conserved Domains (3) summary
      cd15574
      Location:7 → 54
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15709
      Location:61 → 185
      ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
      cd20901
      Location:686 → 740
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    6. XM_039087725.2 → XP_038943653.1  protein AF-17 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K809
      Related
      ENSRNOP00000074424.2, ENSRNOT00000092122.3
      Conserved Domains (3) summary
      cd15574
      Location:7 → 54
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15709
      Location:61 → 185
      ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
      cd20901
      Location:714 → 768
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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