Foxl2 forkhead box L2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxl2provided by RGD
Official Full Name: forkhead box L2provided by RGD
Primary source: RGD:1310041
See related: EnsemblRapid:ENSRNOG00000072374 AllianceGenome:RGD:1310041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear estrogen receptor binding activity; and ubiquitin conjugating enzyme binding activity. Involved in negative regulation of gene expression; response to human chorionic gonadotropin; and response to organic cyclic compound. Predicted to be located in Flemming body and nucleoplasm. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (108392466..108395553)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (99512971..99514500)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (107194492..107197644)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXL2, a transcription factor required for differentiation of the ovary, repressed Dmrt1 promoter through the -3.2 kb/-2.8 kb regulatory region, offering a potential mechanism for Dmrt1 transcriptional silencing in granulosa cells.
Title: Distinct transcriptional mechanisms direct expression of the rat Dmrt1 promoter in sertoli cells and germ cells of transgenic mice.

Submit: New GeneRIF Correction

General gene information

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Markers

BB557226 (e-PCR)
- UniSTS:208429

RH143792 (e-PCR)
- UniSTS:233038

Foxl2 (e-PCR), detects polymorphism
- UniSTS:463206

UniSTS:463208 (e-PCR)
- UniSTS:463208

Foxl2 (e-PCR), detects polymorphism
- UniSTS:463208

D8Got153 (e-PCR)
- UniSTS:111828

AU045128 (e-PCR)
- UniSTS:179957

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase regulator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in extraocular skeletal muscle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female somatic sex determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within granulosa cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in oocyte growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to human chorionic gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.