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    Desi1 desumoylating isopeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Desi1provided by RGD
    Official Full Name
    desumoylating isopeptidase 1provided by RGD
    Primary source
    RGD:1305776
    See related
    EnsemblRapid:ENSRNOG00000005577 AllianceGenome:RGD:1305776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DeSI-1; Pppde2; Fam152b; RGD1305776
    Summary
    Predicted to enable several functions, including deSUMOylase activity; importin-alpha family protein binding activity; and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in protein desumoylation; protein export from nucleus; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Orthologous to human DESI1 (desumoylating isopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 215.3), Brain (RPKM 140.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Desi1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115401613..115422974, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113519974..113542834, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123238332..123259636, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene phosphomannomutase 1 Neighboring gene uncharacterized LOC134479945 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11B Neighboring gene uncharacterized LOC103692950 Neighboring gene X-ray repair cross complementing 6 Neighboring gene small nuclear ribonucleoprotein 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DeSUMOylating isopeptidase: a second class of SUMO protease. Shin EJ, et al. EMBO Rep, 2012 Apr. PMID 22370726, Free PMC Article
    2. Nuclear export of ubiquitinated proteins via the UBIN-POST system. Hirayama S, et al. Proc Natl Acad Sci U S A, 2018 May 1. PMID 29666234, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112918

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deSUMOylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables importin-alpha family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    desumoylating isopeptidase 1
    Names
    PPPDE peptidase domain containing 2
    PPPDE peptidase domain-containing protein 2
    S-depalmitoylase DESI1
    family with sequence similarity 152, member B
    palmitoyl protein thioesterase DESI1
    NP_001020874.1
    XP_038935210.1
    XP_038935211.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025703.1 → NP_001020874.1  desumoylating isopeptidase 1

      See identical proteins and their annotated locations for NP_001020874.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098857
      UniProtKB/Swiss-Prot
      Q4KM30
      UniProtKB/TrEMBL
      A6HT40
      Related
      ENSRNOP00000007424.5, ENSRNOT00000007424.6
      Conserved Domains (1) summary
      pfam05903
      Location:7 → 149
      Peptidase_C97; PPPDE putative peptidase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115401613..115422974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079283.2 → XP_038935211.1  desumoylating isopeptidase 1 isoform X2

      Conserved Domains (1) summary
      pfam05903
      Location:7 → 148
      Peptidase_C97; PPPDE putative peptidase domain

    2. XM_039079282.2 → XP_038935210.1  desumoylating isopeptidase 1 isoform X1

      Conserved Domains (1) summary
      pfam05903
      Location:7 → 33
      Peptidase_C97; PPPDE putative peptidase domain

    RNA

    1. XR_010052977.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM30.1 GenPept UniProtKB/Swiss-Prot:Q4KM30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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