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    Slc45a1 solute carrier family 45, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc45a1provided by RGD
    Official Full Name
    solute carrier family 45, member 1provided by RGD
    Primary source
    RGD:708502
    See related
    EnsemblRapid:ENSRNOG00000018229 AllianceGenome:RGD:708502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnb5; Pasta; Past-A
    Summary
    Enables D-glucose:proton symporter activity and galactose:proton symporter activity. Involved in D-glucose transmembrane transport and galactose transmembrane transport. Predicted to be active in membrane. Orthologous to human SLC45A1 (solute carrier family 45 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 72.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc45a1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166388115..166412183, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161105137..161129375, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (167672134..167696331, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene arginine-glutamic acid dipeptide repeats Neighboring gene uncharacterized LOC134487040 Neighboring gene LYR motif containing 1, pseudogene 1 Neighboring gene uncharacterized LOC120103185 Neighboring gene uncharacterized LOC108351065 Neighboring gene uncharacterized LOC120103045

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain. Shimokawa N, et al. J Neurosci, 2002 Nov 1. PMID 12417639, Free PMC Article
    2. Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Srour M, et al. Am J Hum Genet, 2017 May 4. PMID 28434495, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glucose:proton symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables D-glucose:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactose:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in D-glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sucrose transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proton-associated sugar transporter A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144747.3 → NP_653348.3  proton-associated sugar transporter A

      See identical proteins and their annotated locations for NP_653348.3

      Status: VALIDATED

      Source sequence(s)
      BC093599
      UniProtKB/TrEMBL
      A0A0G2QC36, A6IUD8, F1LNK7, Q566E3
      Related
      ENSRNOP00000024581.6, ENSRNOT00000024581.9
      Conserved Domains (1) summary
      cd17313
      Location:88 → 726
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      166388115..166412183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287159.1 → XP_063143229.1  proton-associated sugar transporter A isoform X1

    2. XM_039109270.2 → XP_038965198.1  proton-associated sugar transporter A isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:3 → 546
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4S3.1 GenPept UniProtKB/Swiss-Prot:Q8K4S3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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