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    Bpifa1 BPI fold containing family A, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bpifa1provided by RGD
    Official Full Name
    BPI fold containing family A, member 1provided by RGD
    Primary source
    RGD:619818
    See related
    EnsemblRapid:ENSRNOG00000013859 AllianceGenome:RGD:619818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plunc
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in several processes, including defense response to symbiont; multicellular organismal-level water homeostasis; and negative regulation of single-species biofilm formation in or on host organism. Located in microvillus. Orthologous to human BPIFA1 (BPI fold containing family A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1629.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bpifa1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163087965..163093708)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142627810..142633553)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149624867..149630610)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene BPI fold containing family A, member 3 Neighboring gene uncharacterized LOC134486304 Neighboring gene BPI fold containing family A, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight. Lindahl M, et al. Electrophoresis, 2001 May. PMID 11425234
    2. SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. Liu Y, et al. Am J Pathol, 2013 May. PMID 23499554, Free PMC Article
    3. Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. Sung YK, et al. J Biol Chem, 2002 Apr 12. PMID 11821380
    4. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Hobbs CA, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Dec. PMID 24124190, Free PMC Article
    5. Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Fornander L, et al. Proteomics Clin Appl, 2011 Oct. PMID 21805676

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial humoral response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response in nasopharyngeal-associated lymphoid tissue IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response in nasopharyngeal-associated lymphoid tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multicellular organismal-level water homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multicellular organismal-level water homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of single-species biofilm formation in or on host organism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of single-species biofilm formation in or on host organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of single-species biofilm formation in or on host organism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sodium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in surfactant homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in surfactant homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BPI fold-containing family A member 1
    Names
    ES cell-related protein
    palate lung and nasal epithelium clone protein
    palate, lung and nasal epithelium associated
    palate, lung, and nasal epithelium carcinoma associated protein
    palate, lung, and nasal epithelium expressed transcript
    protein Plunc

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172031.2 → NP_742028.1  BPI fold-containing family A member 1 precursor

      See identical proteins and their annotated locations for NP_742028.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8K4I4
      UniProtKB/TrEMBL
      A6KHX6
      Related
      ENSRNOP00000018581.3, ENSRNOT00000018581.6
      Conserved Domains (1) summary
      pfam01273
      Location:85 → 248
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      163087965..163093708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104251.2 → XP_038960179.1  BPI fold-containing family A member 1 isoform X1

      Related
      ENSRNOP00000102338.1, ENSRNOT00000138935.1
      Conserved Domains (1) summary
      pfam01273
      Location:109 → 272
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4I4.1 GenPept UniProtKB/Swiss-Prot:Q8K4I4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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