Palld palladin, cytoskeletal associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Palldprovided by RGD
Full Name: palladin, cytoskeletal associated proteinprovided by RGD
Primary source: RGD:2322545
See related: EnsemblRapid:ENSRNOG00000010107 AllianceGenome:RGD:2322545
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Palldl1; AABR07025295.1
Summary: Enables cytoskeletal protein binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of podosome assembly; and trophoblast giant cell differentiation. Located in several cellular components, including Z disc; actin cytoskeleton; and axonal growth cone. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 195.1), Heart (RPKM 175.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (33238943..33632236)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (28228006..28621349)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (31865712..31948168)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
Title: [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Mco10 (e-PCR)
- UniSTS:239959

AU046415 (e-PCR)
- UniSTS:111462

GDB:187424 (e-PCR)
- UniSTS:155553

RH143884 (e-PCR)
- UniSTS:233130

D16Rat18 (e-PCR)
- UniSTS:119483

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ruffle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trophoblast giant cell differentiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	IMP Inferred from Mutant Phenotype more info	PubMed
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: palladin; palladin, cytoskeletal associated protein

Names: palladin-like; palladin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433250.1 → NP_001420179.1 palladin, cytoskeletal associated protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6ADH4
NM_001433251.1 → NP_001420180.1 palladin, cytoskeletal associated protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I5ZQM3, F1M265
NM_001433252.1 → NP_001420181.1 palladin, cytoskeletal associated protein isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6A9U3
NM_001433253.1 → NP_001420182.1 palladin, cytoskeletal associated protein isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016
NM_001433254.1 → NP_001420183.1 palladin, cytoskeletal associated protein isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6ADH4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

33238943..33632236

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094916.2 → XP_038950844.1 palladin isoform X3

Related

ENSRNOP00000080820.2, ENSRNOT00000095888.2

Conserved Domains (6) summary

pfam07679
Location:449 → 546

I-set; Immunoglobulin I-set domain

cd00096
Location:1161 → 1164

Ig; Ig strand A [structural motif]

cd05892
Location:1260 → 1351

IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains

cd05893
Location:1027 → 1118

IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains

cd20972
Location:278 → 369

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:1161 → 1251

Ig; Immunoglobulin domain
XM_039094914.2 → XP_038950842.1 palladin isoform X1

Related

ENSRNOP00000091553.2, ENSRNOT00000111769.2

Conserved Domains (6) summary

pfam07679
Location:449 → 546

I-set; Immunoglobulin I-set domain

cd00096
Location:1161 → 1164

Ig; Ig strand A [structural motif]

cd05892
Location:1260 → 1351

IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains

cd05893
Location:1027 → 1118

IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains

cd20972
Location:278 → 369

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:1161 → 1251

Ig; Immunoglobulin domain
XM_039094915.2 → XP_038950843.1 palladin isoform X2

UniProtKB/TrEMBL

A0A8I6ADH4

Conserved Domains (6) summary

pfam07679
Location:449 → 546

I-set; Immunoglobulin I-set domain

cd00096
Location:1144 → 1147

Ig; Ig strand A [structural motif]

cd05892
Location:1243 → 1334

IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains

cd05893
Location:1010 → 1101

IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains

cd20972
Location:278 → 369

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:1144 → 1234

Ig; Immunoglobulin domain
XM_039094917.2 → XP_038950845.1 palladin isoform X4

UniProtKB/TrEMBL

F1M265

Conserved Domains (5) summary

pfam07679
Location:59 → 156

I-set; Immunoglobulin I-set domain

cd00096
Location:771 → 774

Ig; Ig strand A [structural motif]

cd05892
Location:870 → 961

IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains

cd05893
Location:637 → 728

IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:771 → 861

Ig; Immunoglobulin domain
XM_008771231.4 → XP_008769453.1 palladin isoform X5

Conserved Domains (3) summary

cd00096
Location:315 → 384

Ig; Immunoglobulin domain

cd05893
Location:548 → 622

Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin

pfam07679
Location:432 → 522

I-set; Immunoglobulin I-set domain
XM_008771232.4 → XP_008769454.1 palladin isoform X6

Related

ENSRNOP00000088354.1, ENSRNOT00000116705.2

Conserved Domains (3) summary

cd00096
Location:298 → 367

Ig; Immunoglobulin domain

cd05893
Location:531 → 605

Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin

pfam07679
Location:415 → 505

I-set; Immunoglobulin I-set domain