Glrb glycine receptor, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glrbprovided by RGD
Official Full Name: glycine receptor, betaprovided by RGD
Primary source: RGD:2706
See related: EnsemblRapid:ENSRNOG00000010199 AllianceGenome:RGD:2706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables extracellularly glycine-gated ion channel activity and glycine binding activity. Involved in glycinergic synaptic transmission. Is active in glycinergic synapse and postsynaptic specialization. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 281.3), Adrenal (RPKM 74.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q33

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (168432736..168505614, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (166134616..166207498, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (179768040..179842612, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy.
Title: Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy.
Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish alpha1 and rat alpha1beta recombinant glycine receptors.
Title: Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors.
Study shows that the glycine receptors beta-loop sequences flanking the core-binding site differentially regulate the affinity of the receptor for gephyrin and its trapping at synapses.
Title: Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses.
the role of gephyrin and glycine receptor (GlyR) in vestibular compensation, was investigated.
Title: Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.
The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta.
Title: Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
these data are consistent with roles of Vps35 and Nbea in the retrieval and post-Golgi trafficking of synaptic glycine receptor beta-subunit and possibly other neurotransmitter receptors
Title: The trafficking proteins Vacuolar Protein Sorting 35 and Neurobeachin interact with the glycine receptor β-subunit.
Binding of gephyrin to the GlyR is exclusively mediated by the E domain; the binding site was mapped to one of its sub-domains; a high affinity and low affinity binding site for the GlyRbeta-loop was found on holo-gephyrin and the E domain
Title: Biochemical characterization of the high affinity binding between the glycine receptor and gephyrin.
Putative activation mechanisms were fitted to single-channel recordings at 4 glycine concentrations from rat alpha1beta receptors expressed in HEK293 cells. A substantial conformation change is caused by binding while the channel is still shut.
Title: Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Glrb (e-PCR), detects polymorphism
- UniSTS:506937

RH136698 (e-PCR)
- UniSTS:218787

D2Chm25 (e-PCR)
- UniSTS:517871

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly glycine-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
contributes_to extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
contributes_to extracellularly glycine-gated chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables extracellularly glycine-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly glycine-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly glycine-gated ion channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables extracellularly glycine-gated ion channel activity	TAS Traceable Author Statement more info	PubMed
enables glycine binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to glycine binding	ISO Inferred from Sequence Orthology more info
enables glycine binding	ISO Inferred from Sequence Orthology more info
contributes_to glycine binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome reaction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within righting reflex	ISO Inferred from Sequence Orthology more info
involved_in startle response	ISO Inferred from Sequence Orthology more info
involved_in startle response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in synaptic transmission, glycinergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glycinergic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptic transmission, glycinergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of glycine-gated chloride channel complex	ISO Inferred from Sequence Orthology more info
part_of glycine-gated chloride channel complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed
is_active_in postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glycine receptor subunit beta

Names: glycine receptor 58 kDa subunit; glycine receptor, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053296.2 → NP_445748.1 glycine receptor subunit beta precursor

See identical proteins and their annotated locations for NP_445748.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P20781

UniProtKB/TrEMBL

A0A8I5ZW47, A6J5T1

Related

ENSRNOP00000014170.1, ENSRNOT00000014170.6

Conserved Domains (2) summary

TIGR00860
Location:43 → 495

LIC; Cation transporter family protein

cd19010
Location:79 → 265

LGIC_ECD_GlyR_beta; extracellular domain of glycine receptor beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

168432736..168505614 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281359.1 → XP_063137429.1 glycine receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

P20781

UniProtKB/TrEMBL

A0A8I5ZW47, A6J5T1
XM_063281360.1 → XP_063137430.1 glycine receptor subunit beta isoform X2