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    Arhgap12 Rho GTPase activating protein 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap12provided by RGD
    Official Full Name
    Rho GTPase activating protein 12provided by RGD
    Primary source
    RGD:1310017
    See related
    EnsemblRapid:ENSRNOG00000017791 AllianceGenome:RGD:1310017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 133.0), Thymus (RPKM 131.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap12 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (56284282..56397630)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (51588810..51702417)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (54280815..54394716)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 2 Neighboring gene ribosomal protein S19 like 4 Neighboring gene uncharacterized LOC134482723 Neighboring gene kinesin family member 5B Neighboring gene ribosomal protein S27, pseudogene 6 Neighboring gene uncharacterized LOC120097736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function. Ba W, et al. Cell Rep, 2016 Feb 16. PMID 26854232
    2. Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. Schlam D, et al. Nat Commun, 2015 Oct 14. PMID 26465210, Free PMC Article
    3. miR-199a-5p regulates urothelial permeability and may play a role in bladder pain syndrome. Monastyrskaya K, et al. Am J Pathol, 2013 Feb. PMID 23201090
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in morphogenesis of an epithelial sheet ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107357.2 → NP_001100827.2  rho GTPase-activating protein 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6AN18, D3ZDI5
      Related
      ENSRNOP00000024022.7, ENSRNOT00000024022.8
      Conserved Domains (5) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:646 → 831
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:457 → 568
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      56284282..56397630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254012.5 → XP_006254074.1  rho GTPase-activating protein 12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1Z2, A0A8I6AN18
      Related
      ENSRNOP00000072043.2, ENSRNOT00000084919.3
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:621 → 806
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:432 → 543
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:442 → 541
      PH; PH domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    2. XM_006254013.5 → XP_006254075.1  rho GTPase-activating protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AW83
      Related
      ENSRNOP00000092878.1, ENSRNOT00000117680.2
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:599 → 784
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:410 → 521
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:420 → 519
      PH; PH domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    3. XM_063276459.1 → XP_063132529.1  rho GTPase-activating protein 12 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AW83

    4. XM_063276460.1 → XP_063132530.1  rho GTPase-activating protein 12 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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