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    Inava innate immunity activator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inavaprovided by RGD
    Official Full Name
    innate immunity activatorprovided by RGD
    Primary source
    RGD:1311892
    See related
    EnsemblRapid:ENSRNOG00000025948 AllianceGenome:RGD:1311892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311892
    Summary
    Predicted to be involved in several processes, including intestinal epithelial structure maintenance; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm and nuclear body. Human ortholog(s) of this gene implicated in inflammatory bowel disease 29. Orthologous to human INAVA (innate immunity activator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 21.1), Testes (RPKM 5.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Inava in Genome Data Viewer
    Location:
    13q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50218149..50238430, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47666446..47687383, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (53088438..53108713, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 21B Neighboring gene maestro heat-like repeat family member 3 Neighboring gene mitochondrial ribosomal protein L42 like 1 Neighboring gene uncharacterized LOC120096257 Neighboring gene uncharacterized LOC120096220 Neighboring gene G protein-coupled receptor 25 Neighboring gene calmodulin regulated spectrin-associated protein family, member 2 Neighboring gene uncharacterized LOC134481565

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. Yan J, et al. J Clin Invest, 2017 Jun 1. PMID 28436939, Free PMC Article
    2. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Mohanan V, et al. Science, 2018 Mar 9. PMID 29420262, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in adherens junction maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adherens junction maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intestinal epithelial structure maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to peptidoglycan ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    innate immunity activator protein
    Names
    uncharacterized protein C1orf106 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134502.2 → NP_001127974.1  innate immunity activator protein isoform 2

      See identical proteins and their annotated locations for NP_001127974.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICI2, D3ZL84
      Conserved Domains (1) summary
      pfam11819
      Location:107 → 230
      DUF3338; Domain of unknown function (DUF3338)

    2. NM_001434183.1 → NP_001421112.1  innate immunity activator protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    3. NM_001434195.1 → NP_001421124.1  innate immunity activator protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      50218149..50238430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249920.5 → XP_006249982.1  innate immunity activator protein isoform X1

      Related
      ENSRNOP00000034553.5, ENSRNOT00000035404.7
      Conserved Domains (1) summary
      pfam11819
      Location:108 → 231
      DUF3338; Domain of unknown function (DUF3338)

    2. XM_006249922.5 → XP_006249984.1  innate immunity activator protein isoform X2

      Conserved Domains (1) summary
      pfam11819
      Location:8 → 131
      DUF3338; Domain of unknown function (DUF3338)
    Nucleotide Protein Strain
    Heading Accession and Version

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