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    Polr3f RNA polymerase III subunit F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr3fprovided by RGD
    Official Full Name
    RNA polymerase III subunit Fprovided by RGD
    Primary source
    RGD:1306428
    See related
    EnsemblRapid:ENSRNOG00000007548 AllianceGenome:RGD:1306428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and double-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 69.3), Brain (RPKM 68.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polr3f in Genome Data Viewer
    Location:
    3q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (152361798..152378169)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (131908466..131924838)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (138684685..138701055)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 133 Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RB binding protein 9, serine hydrolase Neighboring gene Sec23 homolog B, COPII coat complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. Lefèvre S, et al. Nat Struct Mol Biol, 2011 Mar. PMID 21358628
    2. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Chiu YH, et al. Cell, 2009 Aug 7. PMID 19631370, Free PMC Article
    3. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
    4. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article
    5. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, et al. Mol Cell Biol, 2002 Nov. PMID 12391170, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC6
    Names
    polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
    polymerase (RNA) III subunit F
    NP_001101254.1
    XP_038960973.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107784.1 → NP_001101254.1  DNA-directed RNA polymerase III subunit RPC6

      See identical proteins and their annotated locations for NP_001101254.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474026
      UniProtKB/TrEMBL
      A0A8I6G3H2, A6K758, D3ZQ56
      Related
      ENSRNOP00000010468.4, ENSRNOT00000010468.7
      Conserved Domains (1) summary
      pfam05158
      Location:67 → 370
      RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      152361798..152378169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105045.2 → XP_038960973.1  DNA-directed RNA polymerase III subunit RPC6 isoform X1

      Conserved Domains (1) summary
      pfam05158
      Location:1 → 231
      RNA_pol_Rpc34; RNA polymerase Rpc34 subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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