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    Kif18a kinesin family member 18A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif18aprovided by RGD
    Official Full Name
    kinesin family member 18Aprovided by RGD
    Primary source
    RGD:1561740
    See related
    EnsemblRapid:ENSRNOG00000005037 AllianceGenome:RGD:1561740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561740
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Involved in cellular response to estradiol stimulus. Predicted to be located in several cellular components, including caveola; kinetochore microtubule; and ruffle. Predicted to be part of kinesin complex. Predicted to be active in mitotic spindle astral microtubule; mitotic spindle midzone; and nucleus. Orthologous to human KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 99.4), Spleen (RPKM 64.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif18a in Genome Data Viewer
    Location:
    3q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (116219007..116279378)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (95764388..95824756)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (100366168..100426867)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6, pseudogene 12 Neighboring gene methyltransferase 15, mitochondrial 12S rRNA N4-cytidine Neighboring gene growth factor receptor bound protein 7, pseudogene 1 Neighboring gene transfer RNA alanine (anticodon GGC) 3 Neighboring gene adenosylhomocysteinase, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Expression of KIF18A in gastric cancer and its association with prognosis]. Wang L, et al. Zhonghua Wei Chang Wai Ke Za Zhi, 2016 May. PMID 27215532
    2. The regulation of MS-KIF18A expression and cross talk with estrogen receptor. Zusev M, et al. PLoS One, 2009 Jul 28. PMID 19636373, Free PMC Article
    3. Kinesin 18A expression: clinical relevance to colorectal cancer progression. Nagahara M, et al. Int J Cancer, 2011 Dec 1. PMID 21213216
    4. The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Mayr MI, et al. Curr Biol, 2007 Mar 20. PMID 17346968
    5. MS-KIF18A, a kinesin, is associated with estrogen receptor. Luboshits G, et al. J Cell Biochem, 2007 Feb 15. PMID 17006958

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF18A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434326.1 → NP_001421255.1  kinesin-like protein KIF18A isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JW74, A6HNZ9, D3ZIA5

    2. NM_001434327.1 → NP_001421256.1  kinesin-like protein KIF18A isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JW74, A6HNZ9, D3ZIA5

    3. NM_001434328.1 → NP_001421257.1  kinesin-like protein KIF18A isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNZ9, D3ZIA5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      116219007..116279378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105450.2 → XP_038961378.1  kinesin-like protein KIF18A isoform X1

      Conserved Domains (1) summary
      cd01370
      Location:11 → 355
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    2. XM_017591908.3 → XP_017447397.2  kinesin-like protein KIF18A isoform X2

      Conserved Domains (1) summary
      cd01370
      Location:11 → 355
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    3. XM_063284155.1 → XP_063140225.1  kinesin-like protein KIF18A isoform X3

    4. XM_039105451.2 → XP_038961379.1  kinesin-like protein KIF18A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW74, A6HNZ9, D3ZIA5
      Conserved Domains (1) summary
      cd01370
      Location:11 → 355
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    5. XM_039105452.2 → XP_038961380.1  kinesin-like protein KIF18A isoform X1

      Related
      ENSRNOP00000069771.3, ENSRNOT00000085176.3
      Conserved Domains (1) summary
      cd01370
      Location:11 → 355
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001137642.1: Suppressed sequence

      Description
      NM_001137642.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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