Klhl3 kelch-like family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Klhl3provided by RGD
Full Name: kelch-like family member 3provided by RGD
Primary source: RGD:1565218
See related: EnsemblRapid:ENSRNOG00000019533 AllianceGenome:RGD:1565218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565218
Summary: Predicted to enable cullin family protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including potassium ion homeostasis; protein K48-linked ubiquitination; and renal sodium ion absorption. Predicted to be located in cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 97.4), Brain (RPKM 30.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (6528114..6651338)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (6523089..6645971)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (6924423..7029374)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA858784 (e-PCR)
- UniSTS:261227

RH127764 (e-PCR)
- UniSTS:211074

BF386148 (e-PCR)
- UniSTS:243593

RH79130 (e-PCR)
- UniSTS:81098

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cullin family protein binding	IEA Inferred from Electronic Annotation more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in distal tubule morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in distal tubule morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in distal tubule morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal absorption	ISO Inferred from Sequence Orthology more info
involved_in renal sodium ion absorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in renal sodium ion absorption	IEA Inferred from Electronic Annotation more info
involved_in renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in renal sodium ion absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kelch-like protein 3

Names: kelch-like 3; kelch-like protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419643.1 → NP_001406572.1 kelch-like protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

Related

ENSRNOP00000081756.2, ENSRNOT00000119182.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

6528114..6651338

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096443.2 → XP_038952371.1 kelch-like protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I6G8D9

Conserved Domains (4) summary

PHA03098
Location:24 → 540

PHA03098; kelch-like protein; Provisional

sd00038
Location:405 → 450

Kelch; KELCH repeat [structural motif]

cd18513
Location:121 → 250

BACK_KLHL3; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3)

cl38908
Location:16 → 123

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_039096444.2 → XP_038952372.1 kelch-like protein 3 isoform X2

Conserved Domains (4) summary

PHA03098
Location:88 → 335

PHA03098; kelch-like protein; Provisional

sd00038
Location:200 → 245

Kelch; KELCH repeat [structural motif]

pfam01344
Location:59 → 103

Kelch_1; Kelch motif

cl28903
Location:1 → 45

BACK; BACK (BTB and C-terminal Kelch) domain
XM_039096445.2 → XP_038952373.1 kelch-like protein 3 isoform X3

Conserved Domains (3) summary

PHA03098
Location:47 → 294

PHA03098; kelch-like protein; Provisional

sd00038
Location:159 → 204

Kelch; KELCH repeat [structural motif]

pfam01344
Location:18 → 62

Kelch_1; Kelch motif