Adam8 ADAM metallopeptidase domain 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam8provided by RGD
Official Full Name: ADAM metallopeptidase domain 8provided by RGD
Primary source: RGD:1566394
See related: EnsemblRapid:ENSRNOG00000017897 AllianceGenome:RGD:1566394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566394
Summary: Predicted to enable several functions, including metal ion binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of defense response; positive regulation of intracellular signal transduction; and positive regulation of leukocyte migration. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and podosome. Predicted to be part of alpha9-beta1 integrin-ADAM8 complex. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 68.0), Spleen (RPKM 32.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (204206206..204218988, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (194776559..194789330, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (212317510..212332895, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis.
Title: ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis.
Notch1-ADAM8 feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression
Title: Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression.
Remote histopathological changes of ischemic cardiac grafts are associated with increased expression of ADAM8 thus emphasizing a global myocardial impact of myocardial infarction.
Title: Myocardial infarction induces early increased remote ADAM8 expression of rat hearts after cardiac arrest.

Submit: New GeneRIF Correction

General gene information

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Markers

AW528396 (e-PCR)
- UniSTS:246602

RH132117 (e-PCR)
- UniSTS:215400

RH131378 (e-PCR)
- UniSTS:214661

BF399127 (e-PCR)
- UniSTS:247537

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor superfamily binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular extravasation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eosinophil migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibronectin-dependent thymocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in signal release	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of alpha9-beta1 integrin-ADAM8 complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dense core granule membrane	ISO Inferred from Sequence Orthology more info
located_in phagolysosome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISO Inferred from Sequence Orthology more info
located_in tertiary granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 8

Names: a disintegrin and metallopeptidase domain 8

NP_001414053.1

EC 3.4.24.-

XP_006230561.1

EC 3.4.24.-

XP_006230562.1

EC 3.4.24.-

XP_006230563.1

EC 3.4.24.-

XP_017445732.1

EC 3.4.24.-

XP_038957188.1

EC 3.4.24.-

XP_038957189.1

EC 3.4.24.-

XP_063127637.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427124.1 → NP_001414053.1 disintegrin and metalloproteinase domain-containing protein 8 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

204206206..204218988 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271567.1 → XP_063127637.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X7
XM_006230501.5 → XP_006230563.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X6

See identical proteins and their annotated locations for XP_006230563.1

UniProtKB/TrEMBL

A0A8I5Y1P5

Related

ENSRNOP00000077537.1, ENSRNOT00000103573.2

Conserved Domains (5) summary

smart00050
Location:412 → 486

DISIN; Homologues of snake disintegrins

smart00608
Location:488 → 607

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:196 → 393

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:196 → 395

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:51 → 149

Pep_M12B_propep; Reprolysin family propeptide
XM_039101261.2 → XP_038957189.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X4

Conserved Domains (5) summary

smart00050
Location:412 → 486

DISIN; Homologues of snake disintegrins

smart00608
Location:488 → 607

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:196 → 395

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:28 → 152

Pep_M12B_propep; Reprolysin family propeptide

NF033761
Location:757 → 842

gliding_GltJ; adventurous gliding motility protein GltJ
XM_039101260.2 → XP_038957188.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X3

Conserved Domains (5) summary

smart00050
Location:412 → 486

DISIN; Homologues of snake disintegrins

smart00608
Location:488 → 607

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:196 → 395

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:28 → 152

Pep_M12B_propep; Reprolysin family propeptide

NF033761
Location:757 → 851

gliding_GltJ; adventurous gliding motility protein GltJ
XM_006230500.5 → XP_006230562.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X2

See identical proteins and their annotated locations for XP_006230562.1

Conserved Domains (5) summary

smart00050
Location:412 → 486

DISIN; Homologues of snake disintegrins

smart00608
Location:488 → 607

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:196 → 393

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:196 → 395

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:51 → 149

Pep_M12B_propep; Reprolysin family propeptide
XM_006230499.5 → XP_006230561.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X1

See identical proteins and their annotated locations for XP_006230561.1

UniProtKB/TrEMBL

D3ZB52

Related

ENSRNOP00000024369.6, ENSRNOT00000024369.8

Conserved Domains (5) summary

smart00050
Location:412 → 486

DISIN; Homologues of snake disintegrins

smart00608
Location:488 → 607

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:196 → 393

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:196 → 395

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:51 → 149

Pep_M12B_propep; Reprolysin family propeptide
XM_017590243.3 → XP_017445732.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X5