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    Sybu syntabulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sybuprovided by RGD
    Official Full Name
    syntabulinprovided by RGD
    Primary source
    RGD:1564335
    See related
    EnsemblRapid:ENSRNOG00000004200 AllianceGenome:RGD:1564335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ocsyn; Golsyn; RGD1564335
    Summary
    Enables microtubule binding activity. Involved in several processes, including axonal transport; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of synaptic activity. Acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus. Located in dense body; microtubule; and vesicle. Orthologous to human SYBU (syntabulin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 141.5), Heart (RPKM 14.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sybu in Genome Data Viewer
    Location:
    7q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (77731662..77833413, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (75847000..75948919, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (83600614..83670121, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PKHD1 like 1 Neighboring gene estrogen receptor binding site associated antigen 9 Neighboring gene uncharacterized LOC134479721 Neighboring gene Smg5 nonsense mediated mRNA decay factor like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ocsyn and mitochondrial-canalicular complexes in vestibular hair cells. Vautrin J, et al. Hear Res, 2006 Dec. PMID 17045436
    2. KIF5B motor adaptor syntabulin maintains synaptic transmission in sympathetic neurons. Ma H, et al. J Neurosci, 2009 Oct 14. PMID 19828815, Free PMC Article
    3. Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons. Xu J, et al. Sci Rep, 2016 Feb 12. PMID 26868290, Free PMC Article
    4. Syntabulin-kinesin-1 family member 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly. Cai Q, et al. J Neurosci, 2007 Jul 4. PMID 17611281, Free PMC Article
    5. The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion. Ying Y, et al. FEBS Lett, 2012 Oct 19. PMID 22975310

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. syntabulin forms a complex with PICK1 and ASICs, regulates ASIC protein expression in neurons, and participates in ASIC-induced acidotoxicity.
      Title: Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons.
    2. Ocsyn may be involved in addressing organelles. We propose that ocsyn is involved in formation of canalicular-mitochondrial complexes.
      Title: Ocsyn and mitochondrial-canalicular complexes in vestibular hair cells.
    3. syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion
      Title: The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde neuronal dense core vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonal transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    syntabulin
    Names
    Golgi-localized protein
    syntabulin (syntaxin-interacting)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427665.1 → NP_001414594.1  syntabulin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZLI6, A6HRC1
      Related
      ENSRNOP00000107368.1, ENSRNOT00000151403.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      77731662..77833413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264119.1 → XP_063120189.1  syntabulin isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZLI6, F1LUC0
      Related
      ENSRNOP00000078572.1, ENSRNOT00000096897.2

    2. XM_039080175.2 → XP_038936103.1  syntabulin isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZLI6, A6HRC1
      Related
      ENSRNOP00000085889.1, ENSRNOT00000111430.2
      Conserved Domains (1) summary
      pfam15290
      Location:215 → 510
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    3. XM_063264118.1 → XP_063120188.1  syntabulin isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZLI6

    4. XM_063264115.1 → XP_063120185.1  syntabulin isoform X1

      UniProtKB/TrEMBL
      A0A8I6A508, A0A8I6AS68
      Related
      ENSRNOP00000097171.1, ENSRNOT00000105901.2

    5. XM_039080176.1 → XP_038936104.1  syntabulin isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZLI6, F1LUC0
      Related
      ENSRNOP00000005584.7, ENSRNOT00000005584.10
      Conserved Domains (1) summary
      pfam15290
      Location:214 → 509
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    6. XM_006241616.3 → XP_006241678.1  syntabulin isoform X4

      See identical proteins and their annotated locations for XP_006241678.1

      UniProtKB/TrEMBL
      A0A8I5ZLI6, A6HRC1
      Conserved Domains (1) summary
      pfam15290
      Location:215 → 510
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    7. XM_063264116.1 → XP_063120186.1  syntabulin isoform X2

      UniProtKB/TrEMBL
      A0A8I6A508

    8. XM_063264117.1 → XP_063120187.1  syntabulin isoform X3

      UniProtKB/TrEMBL
      A0A8I6A508

    9. XM_006241617.4 → XP_006241679.1  syntabulin isoform X5

      See identical proteins and their annotated locations for XP_006241679.1

      UniProtKB/TrEMBL
      A0A8I5ZLI6
      Related
      ENSRNOP00000106185.1, ENSRNOT00000129690.1
      Conserved Domains (1) summary
      pfam15290
      Location:238 → 428
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    10. XM_039080181.2 → XP_038936109.1  syntabulin isoform X9

      Conserved Domains (1) summary
      pfam15290
      Location:5 → 300
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    11. XM_039080180.2 → XP_038936108.1  syntabulin isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZLI6
      Conserved Domains (1) summary
      pfam15290
      Location:77 → 372
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    12. XM_039080178.2 → XP_038936106.1  syntabulin isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZLI6
      Conserved Domains (1) summary
      pfam15290
      Location:78 → 373
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    13. XM_039080183.2 → XP_038936111.1  syntabulin isoform X9

      Conserved Domains (1) summary
      pfam15290
      Location:5 → 300
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    14. XM_039080182.2 → XP_038936110.1  syntabulin isoform X9

      Conserved Domains (1) summary
      pfam15290
      Location:5 → 300
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    Nucleotide Protein Strain
    Heading Accession and Version

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