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    Cspp1 centrosome and spindle pole associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cspp1provided by RGD
    Official Full Name
    centrosome and spindle pole associated protein 1provided by RGD
    Primary source
    RGD:1307055
    See related
    EnsemblRapid:ENSRNOG00000021718 AllianceGenome:RGD:1307055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307055
    Summary
    Predicted to be involved in positive regulation of cytokinesis. Predicted to be located in centriolar satellite and spindle. Predicted to be active in centrosome and spindle pole. Human ortholog(s) of this gene implicated in Joubert syndrome 21. Orthologous to human CSPP1 (centrosome and spindle pole associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 89.2), Kidney (RPKM 76.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cspp1 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (13860072..13975299, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9077161..9192402, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8761293..8876205, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ARF guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC134486914 Neighboring gene uncharacterized LOC134486913 Neighboring gene COP9 signalosome subunit 5 Neighboring gene RNA, U6 small nuclear 1297 Neighboring gene protein phosphatase 1, regulatory subunit 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Asiedu M, et al. Mol Biol Cell, 2009 Mar. PMID 19129481, Free PMC Article
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosome and spindle pole-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191864.2 → NP_001178793.2  centrosome and spindle pole-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZYD5, F1LPI1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      13860072..13975299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110193.1 → XP_038966121.1  centrosome and spindle pole-associated protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    2. XM_039110190.2 → XP_038966118.1  centrosome and spindle pole-associated protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    3. XM_039110189.2 → XP_038966117.1  centrosome and spindle pole-associated protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    4. XM_063287886.1 → XP_063143956.1  centrosome and spindle pole-associated protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A8I6A987

    5. XM_039110201.2 → XP_038966129.1  centrosome and spindle pole-associated protein 1 isoform X34

      UniProtKB/TrEMBL
      A0A8I5ZYD5
      Conserved Domains (1) summary
      PTZ00108
      Location:54 → 405
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    6. XM_006237777.5 → XP_006237839.1  centrosome and spindle pole-associated protein 1 isoform X31

      UniProtKB/TrEMBL
      A0A8I5ZYD5
      Related
      ENSRNOP00000085024.2, ENSRNOT00000097155.2
      Conserved Domains (1) summary
      PTZ00108
      Location:54 → 405
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    7. XM_039110186.2 → XP_038966114.1  centrosome and spindle pole-associated protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZYD5
      Conserved Domains (1) summary
      PTZ00108
      Location:54 → 405
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    8. XM_039110184.2 → XP_038966112.1  centrosome and spindle pole-associated protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZYD5
      Conserved Domains (1) summary
      PTZ00108
      Location:54 → 406
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    9. XM_039110200.2 → XP_038966128.1  centrosome and spindle pole-associated protein 1 isoform X33

      UniProtKB/TrEMBL
      A0A8I6A987
      Conserved Domains (1) summary
      PTZ00108
      Location:54 → 432
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    10. XM_039110182.2 → XP_038966110.1  centrosome and spindle pole-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A987
      Conserved Domains (1) summary
      PTZ00108
      Location:54 → 432
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    11. XM_063287881.1 → XP_063143951.1  centrosome and spindle pole-associated protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A987
      Related
      ENSRNOP00000081772.2, ENSRNOT00000099294.2

    12. XM_039110181.2 → XP_038966109.1  centrosome and spindle pole-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A987
      Conserved Domains (1) summary
      PTZ00108
      Location:54 → 433
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    13. XM_063287885.1 → XP_063143955.1  centrosome and spindle pole-associated protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A8I6A987

    14. XM_006237778.5 → XP_006237840.1  centrosome and spindle pole-associated protein 1 isoform X32

      UniProtKB/TrEMBL
      A0A8I6A987

    15. XM_063287880.1 → XP_063143950.1  centrosome and spindle pole-associated protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A987

    16. XM_006237775.5 → XP_006237837.1  centrosome and spindle pole-associated protein 1 isoform X30

      UniProtKB/TrEMBL
      A0A8I6A987

    17. XM_039110179.2 → XP_038966107.1  centrosome and spindle pole-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A987

    18. XM_006237774.5 → XP_006237836.1  centrosome and spindle pole-associated protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A8I6A987

    19. XM_006237767.5 → XP_006237829.1  centrosome and spindle pole-associated protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A987
      Related
      ENSRNOP00000095654.2, ENSRNOT00000112751.2

    20. XM_006237763.5 → XP_006237825.1  centrosome and spindle pole-associated protein 1 isoform X6

      See identical proteins and their annotated locations for XP_006237825.1

      UniProtKB/TrEMBL
      A0A8I5ZTS7, A0A8I6A987

    21. XM_039110187.2 → XP_038966115.1  centrosome and spindle pole-associated protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A987

    22. XM_039110180.2 → XP_038966108.1  centrosome and spindle pole-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A987

    23. XM_039110178.2 → XP_038966106.1  centrosome and spindle pole-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYG0, A0A8I6A987
      Related
      ENSRNOP00000008480.8, ENSRNOT00000008480.8

    24. XM_063287888.1 → XP_063143958.1  centrosome and spindle pole-associated protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    25. XM_063287883.1 → XP_063143953.1  centrosome and spindle pole-associated protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    26. XM_063287882.1 → XP_063143952.1  centrosome and spindle pole-associated protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZYD5, A0A8I6AK55

    27. XM_039110192.2 → XP_038966120.1  centrosome and spindle pole-associated protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    28. XM_063287887.1 → XP_063143957.1  centrosome and spindle pole-associated protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    29. XM_039110194.2 → XP_038966122.1  centrosome and spindle pole-associated protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZYD5

    30. XM_063287893.1 → XP_063143963.1  centrosome and spindle pole-associated protein 1 isoform X28

    31. XM_063287890.1 → XP_063143960.1  centrosome and spindle pole-associated protein 1 isoform X25

    32. XM_063287889.1 → XP_063143959.1  centrosome and spindle pole-associated protein 1 isoform X24

    33. XM_063287891.1 → XP_063143961.1  centrosome and spindle pole-associated protein 1 isoform X26

    34. XM_039110195.2 → XP_038966123.1  centrosome and spindle pole-associated protein 1 isoform X23

    35. XM_063287892.1 → XP_063143962.1  centrosome and spindle pole-associated protein 1 isoform X27

    36. XM_039110198.2 → XP_038966126.1  centrosome and spindle pole-associated protein 1 isoform X29

    RNA

    1. XR_005504467.2 RNA Sequence

    2. XR_010066406.1 RNA Sequence

    3. XR_005504468.2 RNA Sequence

    4. XR_005504470.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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