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    Astn2 astrotactin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Astn2provided by RGD
    Official Full Name
    astrotactin 2provided by RGD
    Primary source
    RGD:2320342
    See related
    EnsemblRapid:ENSRNOG00000060105 AllianceGenome:RGD:2320342
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and inositol 1,3,4,5 tetrakisphosphate binding activity. Predicted to be involved in neuron migration. Predicted to act upstream of or within establishment of body hair planar orientation and negative regulation of protein localization to cell surface. Predicted to be located in cell pole; endosome; and membrane. Orthologous to human ASTN2 (astrotactin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 111.6), Adrenal (RPKM 20.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Astn2 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (83772988..84759439, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (78758142..79744021, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (81179614..82168528, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit d, mitochondrial-like Neighboring gene pappalysin Neighboring gene tripartite motif-containing 32 Neighboring gene RNA, U6 small nuclear 1015 Neighboring gene H2A.Z variant histone 2, pseudogene 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene toll-like receptor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration. Wilson PM, et al. J Neurosci, 2010 Jun 23. PMID 20573900, Free PMC Article
    2. Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles. Chang H, et al. PLoS Genet, 2015. PMID 26418459, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol 1,3,4,5 tetrakisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol 1,3,4,5 tetrakisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of body hair planar orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    astrotactin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271363.1 → NP_001258292.1  astrotactin-2

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A096MK06
      Related
      ENSRNOP00000075622.2, ENSRNOT00000084959.3
      Conserved Domains (3) summary
      smart00457
      Location:867 → 1050
      MACPF; membrane-attack complex / perforin
      cd00063
      Location:1081 → 1203
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam14670
      Location:718 → 765
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      83772988..84759439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287034.1 → XP_063143104.1  astrotactin-2 isoform X3

    2. XM_017593112.3 → XP_017448601.1  astrotactin-2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYU3
      Related
      ENSRNOP00000070791.2, ENSRNOT00000084147.3

    3. XM_017593110.3 → XP_017448599.2  astrotactin-2 isoform X1

      Conserved Domains (5) summary
      smart00457
      Location:863 → 1046
      MACPF; membrane-attack complex / perforin
      cd00063
      Location:1077 → 1199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam14670
      Location:714 → 761
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      pfam18411
      Location:1201 → 1293
      Annexin_like; Annexin-like domain
      pfam18577
      Location:1297 → 1343
      ASTN_2_hairpin; Astrotactin-2 C-terminal beta-hairpin domain

    4. XM_017593109.3 → XP_017448598.2  astrotactin-2 isoform X4

      Conserved Domains (2) summary
      smart00457
      Location:867 → 1050
      MACPF; membrane-attack complex / perforin
      pfam14670
      Location:718 → 765
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein Strain
    Heading Accession and Version

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