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    Adcy9 adenylate cyclase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302950, updated on 9-Dec-2024

    Summary

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    Symbol
    Adcy9provided by RGD
    Full Name
    adenylate cyclase 9provided by RGD
    Primary source
    RGD:1304747
    See related
    EnsemblRapid:ENSRNOG00000049768 AllianceGenome:RGD:1304747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable adenylate cyclase activity. Involved in cAMP biosynthetic process. Located in axon and dendrite. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 282.3), Brain (RPKM 141.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adcy9 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11645373..11768462)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11138966..11262067)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11392698..11515406)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095031 Neighboring gene uncharacterized LOC120095032 Neighboring gene uncharacterized LOC102551062 Neighboring gene uncharacterized LOC120095034 Neighboring gene uncharacterized LOC120095035 Neighboring gene CREB binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of adenylyl cyclase type IX and calcineurin in synapses of the central nervous system. Sosunov SA, et al. Bull Exp Biol Med, 2001 Feb. PMID 11391406
    2. Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9. Wu Y, et al. Funct Integr Genomics, 2022 Jun. PMID 34988676
    3. Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Strazzabosco M, et al. Hepatology, 2009 Jul. PMID 19444869, Free PMC Article
    4. Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. Toyota T, et al. Am J Med Genet, 2002 Jan 8. PMID 11840511
    5. Characterisation of human adenylyl cyclase IX reveals inhibition by Ca(2+)/Calcineurin and differential mRNA plyadenylation. Paterson JM, et al. J Neurochem, 2000 Oct. PMID 10987815

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9.
      Title: Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase type 9
    NP_001358619.1
    XP_008765747.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371690.1 → NP_001358619.1  adenylate cyclase type 9

      Status: VALIDATED

      Source sequence(s)
      AI058744, JAXUCZ010000010
      UniProtKB/TrEMBL
      A6K4T1
      Conserved Domains (2) summary
      pfam00211
      Location:385 → 573
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01284
      Location:125 → 237
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11645373..11768462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767525.4 → XP_008765747.1  adenylate cyclase type 9 isoform X1

      See identical proteins and their annotated locations for XP_008765747.1

      UniProtKB/TrEMBL
      A0A096MJB0, M0R5U4
      Related
      ENSRNOP00000064773.3, ENSRNOT00000072802.4
      Conserved Domains (3) summary
      smart00044
      Location:326 → 544
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:385 → 573
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam10101
      Location:118 → 193
      DUF2339; Predicted membrane protein (DUF2339)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106980.1: Suppressed sequence

      Description
      NM_001106980.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: ADCY9 (GeneID:395339).
    Nucleotide Protein Strain
    Heading Accession and Version

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