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    Lacc1 laccase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lacc1provided by RGD
    Official Full Name
    laccase domain containing 1provided by RGD
    Primary source
    RGD:1310185
    See related
    EnsemblRapid:ENSRNOG00000022094 AllianceGenome:RGD:1310185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310185
    Summary
    Predicted to enable adenosine deaminase activity; copper ion binding activity; and pentosyltransferase activity. Predicted to be involved in several processes, including positive regulation of cytokine production involved in immune response; regulation of cellular pH; and regulation of defense response. Predicted to be located in endoplasmic reticulum; nucleus; and peroxisome. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis. Orthologous to human LACC1 (laccase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 88.4), Adrenal (RPKM 43.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lacc1 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (58799477..58816840, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (52390267..52407630, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (59199537..59217200, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482156 Neighboring gene uncharacterized LOC102546462 Neighboring gene uncharacterized LOC134482157 Neighboring gene uncharacterized LOC108352946 Neighboring gene coiled-coil domain containing 122 Neighboring gene uncharacterized LOC120097048

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-211-5p in extracellular vesicles derived from BMSCs facilitates the repair of rat frozen shoulder via regulating KDM2B/LACC1 axis. Mao X, et al. Tissue Cell, 2023 Apr. PMID 36610229
    2. LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction. Lu K, et al. Altern Ther Health Med, 2024 Aug. PMID 38064597
    3. C13orf31 (FAMIN) is a central regulator of immunometabolic function. Cader MZ, et al. Nat Immunol, 2016 Sep. PMID 27478939, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
      Title: LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
    2. MicroRNA-211-5p in extracellular vesicles derived from BMSCs facilitates the repair of rat frozen shoulder via regulating KDM2B/LACC1 axis.
      Title: MicroRNA-211-5p in extracellular vesicles derived from BMSCs facilitates the repair of rat frozen shoulder via regulating KDM2B/LACC1 axis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2'-deoxyadenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-methyl-5-thioadenosine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanosine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine-nucleoside phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of purine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    purine nucleoside phosphorylase LACC1
    Names
    laccase (multicopper oxidoreductase) domain containing 1
    laccase domain-containing protein 1
    NP_001386429.1
    XP_038949955.1
    XP_038949957.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399500.1 → NP_001386429.1  purine nucleoside phosphorylase LACC1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3ZCD2
      Related
      ENSRNOP00000036081.4, ENSRNOT00000032301.8
      Conserved Domains (1) summary
      pfam02578
      Location:195 → 426
      Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      58799477..58816840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094029.2 → XP_038949957.1  purine nucleoside phosphorylase LACC1 isoform X2

      Conserved Domains (1) summary
      cl00650
      Location:188 → 311
      Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

    2. XM_039094027.2 → XP_038949955.1  purine nucleoside phosphorylase LACC1 isoform X1

      UniProtKB/TrEMBL
      D3ZCD2
      Conserved Domains (1) summary
      pfam02578
      Location:195 → 426
      Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase
    Nucleotide Protein Strain
    Heading Accession and Version

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