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    Rev1 REV1, DNA directed polymerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rev1provided by RGD
    Official Full Name
    REV1, DNA directed polymeraseprovided by RGD
    Primary source
    RGD:1306715
    See related
    EnsemblRapid:ENSRNOG00000018623 AllianceGenome:RGD:1306715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rev1l
    Summary
    Predicted to enable DNA-directed DNA polymerase activity and deoxycytidyl transferase activity. Predicted to be involved in error-free translesion synthesis; error-prone translesion synthesis; and response to UV. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 142.9), Adrenal (RPKM 125.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rev1 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47773907..47847554, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (40278100..40351764, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44714137..44786330, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 9 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene uncharacterized LOC134480569 Neighboring gene transfer RNA threonine (anticodon AGU) 33 Neighboring gene ALF transcription elongation factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein. Masuda Y, et al. J Biol Chem, 2002 Jan 25. PMID 11711549
    2. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. Murakumo Y, et al. J Biol Chem, 2001 Sep 21. PMID 11485998
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxycytidyl transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxycytidyl transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-free translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein REV1
    Names
    REV1 homolog
    REV1, polymerase (DNA directed)
    REV1-like
    NP_001381058.2
    XP_008765252.1
    XP_017451933.1
    XP_017451934.1
    XP_017451935.1
    XP_038939504.1
    XP_038939505.1
    XP_038939506.1
    XP_038939507.1
    XP_038939508.1
    XP_063123228.1
    XP_063123229.1
    XP_063123230.1
    XP_063123231.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394129.2 → NP_001381058.2  DNA repair protein REV1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZJ91, D3ZRU9
      Related
      ENSRNOP00000076682.2, ENSRNOT00000111097.2
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1140 → 1233
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    RNA

    1. NR_172081.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      47773907..47847554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083577.2 → XP_038939505.1  DNA repair protein REV1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ91, D3ZRU9
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1140 → 1233
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    2. XM_063267161.1 → XP_063123231.1  DNA repair protein REV1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZJ91

    3. XM_039083578.2 → XP_038939506.1  DNA repair protein REV1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ91, D3ZRU9
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1140 → 1233
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    4. XM_039083576.2 → XP_038939504.1  DNA repair protein REV1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ91, D3ZRU9
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1140 → 1233
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    5. XM_063267160.1 → XP_063123230.1  DNA repair protein REV1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZJ91

    6. XM_063267159.1 → XP_063123229.1  DNA repair protein REV1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZJ91

    7. XM_063267158.1 → XP_063123228.1  DNA repair protein REV1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ91, D3ZRU9

    8. XM_039083579.1 → XP_038939507.1  DNA repair protein REV1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ91, D3ZRU9
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1140 → 1233
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    9. XM_039083580.1 → XP_038939508.1  DNA repair protein REV1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ91, D3ZRU9
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1140 → 1233
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    10. XM_008767030.3 → XP_008765252.1  DNA repair protein REV1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZJ91
      Conserved Domains (4) summary
      cd01701
      Location:131 → 607
      PolY_Rev1; DNA polymerase Rev1
      PRK14133
      Location:202 → 607
      PRK14133; DNA polymerase IV; Provisional
      pfam14377
      Location:721 → 841
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:897 → 1018
      REV1_C; DNA repair protein REV1 C-terminal domain

    11. XM_017596445.3 → XP_017451934.1  DNA repair protein REV1 isoform X6

    12. XM_017596444.3 → XP_017451933.1  DNA repair protein REV1 isoform X6

    13. XM_017596446.2 → XP_017451935.1  DNA repair protein REV1 isoform X6

    RNA

    1. XR_010054595.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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