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    Rab30 RAB30, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab30provided by RGD
    Official Full Name
    RAB30, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1309507
    See related
    EnsemblRapid:ENSRNOG00000077006 AllianceGenome:RGD:1309507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rsb30
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in Golgi organization and vesicle-mediated transport. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi cisterna and trans-Golgi network. Orthologous to human RAB30 (RAB30, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 81.0), Liver (RPKM 54.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab30 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (156216137..156310778)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (146803719..146898369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (157573344..157667973)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3a, pseudogene 1 Neighboring gene uncharacterized LOC100912031 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene DNA damage-induced apoptosis suppressor Neighboring gene prolylcarboxypeptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab30 is required for the morphological integrity of the Golgi apparatus. Kelly EE, et al. Biol Cell, 2012 Feb. PMID 22188167
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108822

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015012.3 → NP_001015012.1  ras-related protein Rab-30 isoform b

      See identical proteins and their annotated locations for NP_001015012.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ANI9, Q5BK72
      Conserved Domains (1) summary
      cl38936
      Location:3 → 143
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001399386.2 → NP_001386315.1  ras-related protein Rab-30 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JTT4, A6I665
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    3. NM_001399387.2 → NP_001386316.1  ras-related protein Rab-30 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JTT4, A6I665
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    4. NM_001399388.2 → NP_001386317.1  ras-related protein Rab-30 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JTT4, A6I665
      Related
      ENSRNOP00000107777.1, ENSRNOT00000130424.1
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    5. NM_001399389.2 → NP_001386318.1  ras-related protein Rab-30 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JTT4, A6I665
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    6. NM_001399390.2 → NP_001386319.1  ras-related protein Rab-30 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ANI9, Q5BK72
      Related
      ENSRNOP00000102633.1, ENSRNOT00000141093.1
      Conserved Domains (1) summary
      cl38936
      Location:3 → 143
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_174183.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      156216137..156310778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262746.1 → XP_063118816.1  ras-related protein Rab-30 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTT4, A6I665

    2. XM_063262747.1 → XP_063118817.1  ras-related protein Rab-30 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ANI9, Q5BK72

    3. XM_017589171.3 → XP_017444660.1  ras-related protein Rab-30 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTT4, A6I665
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)
    Nucleotide Protein Strain
    Heading Accession and Version

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