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    Tax1bp1 Tax1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tax1bp1provided by RGD
    Official Full Name
    Tax1 binding protein 1provided by RGD
    Primary source
    RGD:708579
    See related
    EnsemblRapid:ENSRNOG00000008393 AllianceGenome:RGD:708579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aa1076
    Summary
    Predicted to enable kinase binding activity and protein-macromolecule adaptor activity. Involved in negative regulation of apoptotic process. Predicted to be located in autophagosome; cytoplasmic vesicle; and phagophore assembly site. Predicted to be active in mitochondrion. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 592.6), Lung (RPKM 576.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tax1bp1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (83152549..83208463)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (81821991..81877906)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (82776720..82832586)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486582 Neighboring gene uncharacterized LOC134486581 Neighboring gene JAZF zinc finger 1 Neighboring gene uncharacterized LOC108350711 Neighboring gene serine and arginine rich splicing factor 7, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell therapy modulates expression of Tax1-binding protein 1 and synaptotagmin IV in a model of optic nerve lesion. Mesentier-Louro LA, et al. Invest Ophthalmol Vis Sci, 2012 Jul 12. PMID 22695963
    2. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Sarraf SA, et al. Mol Cell, 2020 Dec 3. PMID 33207181, Free PMC Article
    3. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. De Valck D, et al. Oncogene, 1999 Jul 22. PMID 10435631
    4. Regulation of NF-κB by ubiquitination. Chen J, et al. Curr Opin Immunol, 2013 Feb. PMID 23312890, Free PMC Article
    5. Deubiquitinases in the regulation of NF-κB signaling. Harhaj EW, et al. Cell Res, 2011 Jan. PMID 21119682, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
      Title: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
    2. The increased expression of Tax1BP1 in optic nerve crush eyes displays the possible neuroprotective effect of bone marrow mononuclear cell treatment
      Title: Cell therapy modulates expression of Tax1-binding protein 1 and synaptotagmin IV in a model of optic nerve lesion.
    3. C-terminal region of Tax1BP1 bound to an intracellular domain of the rho1 subunit, but not to other subunits of GABA(C), GABA(A) or glycine receptors. Tax1BP1 & GABA(C) receptors were co-expressed in both synaptic layers of the retina.
      Title: Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94031

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tax1-binding protein 1 homolog
    Names
    TRAF6-binding protein homolog
    Tax1 (human T-cell leukemia virus type I) binding protein 1
    liver regeneration-related protein 2
    liver regeneration-related protein LRRG004

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004199.1 → NP_001004199.1  tax1-binding protein 1 homolog

      See identical proteins and their annotated locations for NP_001004199.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081949
      UniProtKB/Swiss-Prot
      Q66HA4, Q7TQ13
      UniProtKB/TrEMBL
      A0A8I6ABW0
      Related
      ENSRNOP00000089029.2, ENSRNOT00000104919.2
      Conserved Domains (5) summary
      TIGR02168
      Location:352 → 641
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07888
      Location:125 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:17 → 120
      SKICH; SKICH domain
      pfam18112
      Location:752 → 778
      Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
      cd21970
      Location:779 → 805
      Zn-C2H2_TAX1BP1_rpt2; second C2H2-type zinc binding domain found in tax1-binding protein 1 (TAX1BP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      83152549..83208463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236480.5 → XP_006236542.1  tax1-binding protein 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006236542.1

      UniProtKB/TrEMBL
      A0A8I6ABW0
      Conserved Domains (2) summary
      pfam07888
      Location:17 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      cl23720
      Location:171 → 261
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_063285555.1 → XP_063141625.1  tax1-binding protein 1 homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6ABW0

    3. XM_017592467.3 → XP_017447956.1  tax1-binding protein 1 homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6ABW0
      Conserved Domains (5) summary
      COG4372
      Location:338 → 669
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam07888
      Location:125 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:17 → 120
      SKICH; SKICH domain
      pfam18112
      Location:728 → 754
      Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
      cl41777
      Location:755 → 781
      Zn-C2H2_CALCOCO1_TAX1BP1_like; autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins

    4. XM_006236482.5 → XP_006236544.1  tax1-binding protein 1 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABW0
      Conserved Domains (2) summary
      pfam07888
      Location:17 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      cl23720
      Location:171 → 261
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. XM_006236483.5 → XP_006236545.1  tax1-binding protein 1 homolog isoform X4

      See identical proteins and their annotated locations for XP_006236545.1

      UniProtKB/TrEMBL
      A0A8I6ABW0, A6K0S8
      Conserved Domains (5) summary
      TIGR02168
      Location:352 → 640
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07888
      Location:125 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:17 → 120
      SKICH; SKICH domain
      pfam18112
      Location:751 → 777
      Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
      cl41777
      Location:778 → 804
      Zn-C2H2_CALCOCO1_TAX1BP1_like; autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins

    6. XM_017592468.3 → XP_017447957.1  tax1-binding protein 1 homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I6ABW0
      Conserved Domains (5) summary
      COG4372
      Location:338 → 668
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam07888
      Location:125 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:17 → 120
      SKICH; SKICH domain
      pfam18112
      Location:727 → 753
      Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
      cl41777
      Location:754 → 780
      Zn-C2H2_CALCOCO1_TAX1BP1_like; autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins

    7. XM_006236481.5 → XP_006236543.1  tax1-binding protein 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006236543.1

      UniProtKB/TrEMBL
      A0A8I6ABW0
      Conserved Domains (2) summary
      pfam07888
      Location:17 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      cl23720
      Location:171 → 261
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    8. XM_039107045.2 → XP_038962973.1  tax1-binding protein 1 homolog isoform X3

      UniProtKB/Swiss-Prot
      Q66HA4, Q7TQ13
      UniProtKB/TrEMBL
      A0A8I6ABW0
      Conserved Domains (5) summary
      TIGR02168
      Location:352 → 641
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07888
      Location:125 → 460
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:17 → 120
      SKICH; SKICH domain
      pfam18112
      Location:752 → 778
      Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
      cd21970
      Location:779 → 805
      Zn-C2H2_TAX1BP1_rpt2; second C2H2-type zinc binding domain found in tax1-binding protein 1 (TAX1BP1) and similar proteins

    9. XM_063285556.1 → XP_063141626.1  tax1-binding protein 1 homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6ABW0
      Related
      ENSRNOP00000046052.3, ENSRNOT00000041988.7

    10. XM_063285552.1 → XP_063141622.1  tax1-binding protein 1 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABW0

    11. XM_063285554.1 → XP_063141624.1  tax1-binding protein 1 homolog isoform X4

      UniProtKB/TrEMBL
      A0A8I6ABW0, A6K0S8

    12. XM_063285550.1 → XP_063141620.1  tax1-binding protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABW0

    13. XM_063285553.1 → XP_063141623.1  tax1-binding protein 1 homolog isoform X3

      UniProtKB/Swiss-Prot
      Q66HA4, Q7TQ13
      UniProtKB/TrEMBL
      A0A8I6ABW0

    14. XM_063285551.1 → XP_063141621.1  tax1-binding protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABW0

    RNA

    1. XR_005503148.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HA4.1 GenPept UniProtKB/Swiss-Prot:Q66HA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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