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    Sptbn2 spectrin, beta, non-erythrocytic 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29211, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sptbn2provided by RGD
    Official Full Name
    spectrin, beta, non-erythrocytic 2provided by RGD
    Primary source
    RGD:3751
    See related
    EnsemblRapid:ENSRNOG00000058842 AllianceGenome:RGD:3751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spnb3
    Summary
    Predicted to enable actin filament binding activity. Predicted to be a structural constituent of postsynapse. Involved in cellular response to ethanol and synaptic vesicle exocytosis. Located in Golgi membrane; cytoplasmic vesicle; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14 and spinocerebellar ataxia type 5. Orthologous to human SPTBN2 (spectrin beta, non-erythrocytic 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 641.4), Kidney (RPKM 105.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Sptbn2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211432373..211473016)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202002970..202045343)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219964429..220006811)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene uncharacterized LOC102553046 Neighboring gene proteasome subunit alpha type-3-like Neighboring gene RNA binding motif protein 14 Neighboring gene RNA binding motif protein 4B Neighboring gene RNA binding motif protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding  
    enables actin filament binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton PubMed 
    enables structural constituent of postsynapse  
    enables structural constituent of postsynapse  
    enables structural constituent of synapse  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in actin filament capping  
    involved_in adult behavior  
    acts_upstream_of_or_within adult behavior  
    involved_in cellular response to ethanol PubMed 
    involved_in cerebellar Purkinje cell layer morphogenesis  
    acts_upstream_of_or_within cerebellar Purkinje cell layer morphogenesis  
    involved_in cytoskeleton organization  
    involved_in multicellular organism growth  
    acts_upstream_of_or_within multicellular organism growth  
    involved_in postsynapse organization  
    involved_in postsynapse organization  
    involved_in regulation of calcium ion-dependent exocytosis PubMed 
    involved_in regulation of postsynaptic specialization assembly  
    involved_in regulation of postsynaptic specialization assembly  
    involved_in synapse assembly  
    acts_upstream_of_or_within synapse assembly  
    involved_in synaptic vesicle docking PubMed 
    involved_in synaptic vesicle exocytosis PubMed 
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    located_in Golgi membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    is_active_in cell junction  
    is_active_in cell projection  
    is_active_in cortical actin cytoskeleton  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in endosome PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in membrane  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in nuclear matrix PubMed 
    located_in parallel fiber to Purkinje cell synapse  
    is_active_in parallel fiber to Purkinje cell synapse  
    located_in paranodal junction  
    is_active_in paranodal junction  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic spectrin-associated cytoskeleton  
    is_active_in postsynaptic spectrin-associated cytoskeleton  
    located_in presynapse  
    is_active_in presynapse  
    part_of spectrin  
    part_of spectrin  
    part_of spectrin PubMed 
    located_in synaptic vesicle PubMed 
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    spectrin beta chain, non-erythrocytic 2
    Names
    beta SpIII sigma 1
    beta-III spectrin
    beta-spectrin 3
    glutamate transporter EAAT4-associated protein 41
    spectrin beta chain, brain 2
    spectrin, non-erythroid beta chain 2
    spectrin-like protein GTRAP41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019167.2NP_062040.2  spectrin beta chain, non-erythrocytic 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88197, Q9ES68, Q9QWN8
      UniProtKB/TrEMBL
      A6HYY4
      Related
      ENSRNOP00000110491.1, ENSRNOT00000173448.1
      Conserved Domains (7) summary
      smart00150
      Location:20182075
      SPEC; Spectrin repeats
      smart00033
      Location:61159
      CH; Calponin homology domain
      cd00014
      Location:177280
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:13841588
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:22212324
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:22422324
      PH; PH domain
      pfam00435
      Location:429522
      Spectrin; Spectrin repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211432373..211473016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760094.4XP_008758316.1  spectrin beta chain, non-erythrocytic 2 isoform X2

      See identical proteins and their annotated locations for XP_008758316.1

      UniProtKB/Swiss-Prot
      O88197, Q9ES68, Q9QWN8
      UniProtKB/TrEMBL
      A6HYY4
      Conserved Domains (7) summary
      smart00150
      Location:20182075
      SPEC; Spectrin repeats
      smart00033
      Location:61159
      CH; Calponin homology domain
      cd00014
      Location:177280
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:13841588
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:22212324
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:22422324
      PH; PH domain
      pfam00435
      Location:429522
      Spectrin; Spectrin repeat
    2. XM_039103158.2XP_038959086.1  spectrin beta chain, non-erythrocytic 2 isoform X3

      UniProtKB/Swiss-Prot
      O88197, Q9ES68, Q9QWN8
      Conserved Domains (6) summary
      smart00150
      Location:20252082
      SPEC; Spectrin repeats
      cd00176
      Location:13911595
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:22282321
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00435
      Location:436529
      Spectrin; Spectrin repeat
      cd21246
      Location:52166
      CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily
      cd21321
      Location:180298
      CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
    3. XM_008760092.4XP_008758314.1  spectrin beta chain, non-erythrocytic 2 isoform X1

      UniProtKB/Swiss-Prot
      O88197, Q9ES68, Q9QWN8
      UniProtKB/TrEMBL
      A0A8I6A0L7
      Related
      ENSRNOP00000086115.1, ENSRNOT00000099903.2
      Conserved Domains (7) summary
      smart00150
      Location:20252082
      SPEC; Spectrin repeats
      smart00033
      Location:68166
      CH; Calponin homology domain
      cd00014
      Location:184287
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:13911595
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:22282331
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:22492331
      PH; PH domain
      pfam00435
      Location:436529
      Spectrin; Spectrin repeat
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