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    Ctsl cathepsin L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25697, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctslprovided by RGD
    Official Full Name
    cathepsin Lprovided by RGD
    Primary source
    RGD:2448
    See related
    EnsemblRapid:ENSRNOG00000018566 AllianceGenome:RGD:2448
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CatL; CATHL; Ctsl1
    Summary
    Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; decidualization; and response to odorant. Located in several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (cathepsin V). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 13282.8), Liver (RPKM 4121.4) and 6 other tissues See more
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    Genomic context

    See Ctsl in Genome Data Viewer
    Location:
    17p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (770104..776266)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (764370..770533)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1873105..1879266, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 20 Neighboring gene serine/arginine-rich splicing factor 3-like Neighboring gene U6 spliceosomal RNA Neighboring gene peroxiredoxin like 2C Neighboring gene transfer RNA serine (anticodon AGA) 40

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity PubMed 
    enables collagen binding  
    enables cysteine-type carboxypeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity PubMed 
    enables cysteine-type endopeptidase activity  
    enables cysteine-type peptidase activity  
    enables cysteine-type peptidase activity  
    enables endopeptidase activity  
    enables fibronectin binding  
    enables histone binding  
    enables kininogen binding PubMed 
    enables metal ion binding  
    enables peptide binding PubMed 
    enables protein-containing complex binding PubMed 
    enables proteoglycan binding  
    enables serpin family protein binding  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in CD4-positive, alpha-beta T cell lineage commitment  
    involved_in CD4-positive, alpha-beta T cell lineage commitment  
    involved_in Sertoli cell differentiation PubMed 
    involved_in adaptive immune response  
    involved_in antigen processing and presentation of peptide antigen  
    involved_in antigen processing and presentation of peptide antigen  
    involved_in apoptotic process  
    involved_in autophagic cell death PubMed 
    involved_in cellular response to starvation PubMed 
    involved_in cellular response to thyroid hormone stimulus  
    involved_in collagen catabolic process  
    involved_in collagen catabolic process  
    involved_in decidualization PubMed 
    acts_upstream_of_or_within decidualization  
    involved_in elastin catabolic process  
    involved_in elastin catabolic process  
    involved_in enkephalin processing  
    NOT involved_in epithelial tube branching involved in lung morphogenesis  
    involved_in fusion of virus membrane with host endosome membrane  
    involved_in fusion of virus membrane with host plasma membrane  
    acts_upstream_of_or_within hair follicle morphogenesis  
    acts_upstream_of keratinocyte proliferation  
    involved_in male gonad development PubMed 
    acts_upstream_of_or_within negative regulation of keratinocyte proliferation  
    involved_in nerve development PubMed 
    involved_in protein autoprocessing  
    involved_in protein autoprocessing  
    involved_in protein catabolic process PubMed 
    involved_in proteolysis PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in proteolysis involved in protein catabolic process  
    involved_in proteolysis involved in protein catabolic process  
    involved_in receptor-mediated endocytosis of virus by host cell  
    involved_in response to glucocorticoid PubMed 
    involved_in response to glucose PubMed 
    involved_in response to gonadotropin PubMed 
    involved_in response to odorant PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in spermatogenesis PubMed 
    involved_in symbiont entry into host cell  
    involved_in thyroid hormone generation  
    involved_in zymogen activation  
    involved_in zymogen activation  
    Items 1 - 25 of 44
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in apical part of cell PubMed 
    located_in apical plasma membrane  
    located_in chromaffin granule  
    located_in cytoplasmic vesicle  
    located_in external side of plasma membrane PubMed 
    located_in external side of plasma membrane  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    is_active_in lysosome  
    located_in lysosome  
    located_in lysosome  
    located_in microvillus PubMed 
    located_in multivesicular body  
    located_in nucleolus  
    located_in nucleus  
    located_in perikaryon PubMed 
    located_in plasma membrane  
    located_in secretory granule PubMed 
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    procathepsin L
    Names
    CP-2
    MEP
    cathepsin L1
    cyclic protein 2
    major excreted protein
    NP_037288.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013156.2NP_037288.1  procathepsin L preproprotein

      See identical proteins and their annotated locations for NP_037288.1

      Status: PROVISIONAL

      Source sequence(s)
      Y00697
      UniProtKB/Swiss-Prot
      P07154, Q9QV07
      UniProtKB/TrEMBL
      I2FHN3
      Related
      ENSRNOP00000093716.2, ENSRNOT00000111570.2
      Conserved Domains (2) summary
      smart00848
      Location:2987
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:114332
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      770104..776266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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