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    Errfi1 ERBB receptor feedback inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313729, updated on 4-Jan-2025

    Summary

    Official Symbol
    Errfi1provided by RGD
    Official Full Name
    ERBB receptor feedback inhibitor 1provided by RGD
    Primary source
    RGD:1307599
    See related
    EnsemblRapid:ENSRNOG00000058186 AllianceGenome:RGD:1307599
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Xxx; Ralt; gene 33; RGD1307599
    Summary
    Enables SH3 domain binding activity; kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; and negative regulation of metabolic process. Predicted to be located in cytosol and plasma membrane. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 791.9), Kidney (RPKM 289.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Errfi1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166606841..166620124)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161323981..161337289)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (167951564..167966011)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351065 Neighboring gene uncharacterized LOC120103045 Neighboring gene uncharacterized LOC102556220 Neighboring gene uncharacterized LOC102556316 Neighboring gene Parkinsonism associated deglycase Neighboring gene TNF receptor superfamily member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding PubMed 
    enables kinase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables small GTPase binding PubMed 
    Items 1 - 25 of 97
    Process Evidence Code Pubs
    involved_in apoptotic process  
    acts_upstream_of_or_within apoptotic process  
    involved_in bile acid biosynthetic process  
    acts_upstream_of_or_within bile acid biosynthetic process  
    involved_in cartilage development  
    acts_upstream_of_or_within cartilage development  
    involved_in cell migration  
    acts_upstream_of_or_within cell migration  
    involved_in cellular hyperosmotic response PubMed 
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    involved_in cholesterol homeostasis  
    acts_upstream_of_or_within cholesterol homeostasis  
    involved_in cholesterol metabolic process  
    acts_upstream_of_or_within cholesterol metabolic process  
    involved_in chondrocyte proliferation  
    acts_upstream_of_or_within chondrocyte proliferation  
    involved_in embryo implantation  
    acts_upstream_of_or_within embryo implantation  
    involved_in epidermal growth factor receptor signaling pathway  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway  
    involved_in epithelial cell proliferation  
    acts_upstream_of_or_within epithelial cell proliferation  
    acts_upstream_of_or_within epithelium development  
    involved_in fat pad development  
    acts_upstream_of_or_within fat pad development  
    involved_in gene expression  
    acts_upstream_of_or_within gene expression  
    involved_in glucose metabolic process  
    acts_upstream_of_or_within glucose metabolic process  
    involved_in limb joint morphogenesis  
    acts_upstream_of_or_within limb joint morphogenesis  
    acts_upstream_of_or_within lipid metabolic process  
    involved_in liver development  
    acts_upstream_of_or_within liver development  
    involved_in lung alveolus development  
    involved_in lung alveolus development  
    involved_in lung alveolus development  
    involved_in lung epithelium development  
    involved_in lung epithelium development  
    involved_in lung epithelium development  
    involved_in lung vasculature development  
    involved_in lung vasculature development  
    involved_in lung vasculature development  
    involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress PubMed 
    involved_in negative regulation of collagen biosynthetic process PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor-activated receptor activity PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity  
    involved_in negative regulation of epidermal growth factor-activated receptor activity  
    involved_in negative regulation of interleukin-1 beta production PubMed 
    involved_in negative regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in negative regulation of protein autophosphorylation  
    involved_in negative regulation of protein autophosphorylation  
    acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation  
    involved_in negative regulation of tumor necrosis factor production PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in progesterone receptor signaling pathway  
    acts_upstream_of_or_within progesterone receptor signaling pathway  
    involved_in protein localization to plasma membrane  
    acts_upstream_of_or_within protein localization to plasma membrane  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of keratinocyte differentiation  
    acts_upstream_of_or_within regulation of protein tyrosine kinase activity  
    acts_upstream_of_or_within regulation of signaling receptor activity  
    involved_in regulation of type B pancreatic cell proliferation PubMed 
    involved_in response to 1-oleoyl-sn-glycerol 3-phosphate  
    acts_upstream_of_or_within response to 1-oleoyl-sn-glycerol 3-phosphate  
    involved_in response to estradiol  
    acts_upstream_of_or_within response to estradiol  
    involved_in response to insulin  
    acts_upstream_of_or_within response to insulin  
    involved_in response to progesterone  
    acts_upstream_of_or_within response to progesterone  
    acts_upstream_of_or_within response to steroid hormone  
    involved_in response to xenobiotic stimulus  
    acts_upstream_of_or_within response to xenobiotic stimulus  
    acts_upstream_of_or_within skeletal system development  
    acts_upstream_of_or_within skin development  
    involved_in skin morphogenesis  
    involved_in skin morphogenesis  
    involved_in skin morphogenesis  
    involved_in tissue homeostasis  
    acts_upstream_of_or_within tissue homeostasis  
    involved_in uterine epithelium development  
    acts_upstream_of_or_within uterine epithelium development  
    acts_upstream_of_or_within uterus development  
    Items 1 - 25 of 97
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in endomembrane system  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ERBB receptor feedback inhibitor 1
    Names
    gene 33 polypeptide
    mig-6
    mitogen-inducible gene 6 protein homolog
    receptor-associated late transducer

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014071.1NP_001014093.1  ERBB receptor feedback inhibitor 1

      See identical proteins and their annotated locations for NP_001014093.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083845
      UniProtKB/Swiss-Prot
      P05432
      UniProtKB/TrEMBL
      A0A8L2R6B1, A6IUE1
      Related
      ENSRNOP00000072811.3, ENSRNOT00000085315.3
      Conserved Domains (2) summary
      pfam09027
      Location:467
      GTPase_binding; GTPase binding
      pfam11555
      Location:313365
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      166606841..166620124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764262.4XP_008762484.1  ERBB receptor feedback inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R6B1
      Conserved Domains (2) summary
      pfam09027
      Location:466
      GTPase_binding; GTPase binding
      pfam11555
      Location:237289
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
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