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    Pnpla4 patatin like phospholipase domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363471, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pnpla4provided by RGD
    Official Full Name
    patatin like phospholipase domain containing 4provided by RGD
    Primary source
    RGD:1562200
    See related
    EnsemblRapid:ENSRNOG00000026157 AllianceGenome:RGD:1562200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562200
    Summary
    Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA4 (patatin like phospholipase domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 40.6), Kidney (RPKM 35.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pnpla4 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (46200351..46205517, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (42313554..42318451, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (45519406..45522988, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase 3-like 1 Neighboring gene steroid sulfatase Neighboring gene prostaglandin E2 receptor EP2 subtype-like Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acylglycerol O-acyltransferase activity  
    enables diolein transacylation activity  
    enables mono-olein transacylation activity  
    enables phospholipase A2 activity  
    enables retinyl-palmitate esterase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    Process Evidence Code Pubs
    involved_in lipid homeostasis  
    involved_in retinol metabolic process  
    involved_in triglyceride catabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in lipid droplet  
    is_active_in membrane  
    located_in mitochondrion  

    General protein information

    Preferred Names
    patatin-like phospholipase domain-containing protein 4
    NP_001388110.1
    NP_001388111.1
    NP_001388112.1
    XP_006257030.1
    XP_006257031.1
    XP_008771463.1
    XP_038956156.1
    XP_038956157.1
    XP_063136208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401181.1NP_001388110.1  patatin-like phospholipase domain-containing protein 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4A227
      Related
      ENSRNOP00000100393.1, ENSRNOT00000143064.1
    2. NM_001401182.1NP_001388111.1  patatin-like phospholipase domain-containing protein 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4A227
    3. NM_001401183.1NP_001388112.1  patatin-like phospholipase domain-containing protein 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      46200351..46205517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100229.2XP_038956157.1  patatin-like phospholipase domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      D4A227
      Conserved Domains (1) summary
      cd07222
      Location:12234
      Pat_PNPLA4; Patatin-like phospholipase domain containing protein 4
    2. XM_006256968.4XP_006257030.1  patatin-like phospholipase domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006257030.1

      UniProtKB/TrEMBL
      D4A227
      Conserved Domains (1) summary
      cd07222
      Location:5249
      Pat_PNPLA4; Patatin-like phospholipase domain containing protein 4
    3. XM_008773241.3XP_008771463.1  patatin-like phospholipase domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_008771463.1

      Conserved Domains (1) summary
      cl11396
      Location:1175
      Patatin_and_cPLA2; Patatins and Phospholipases
    4. XM_063280138.1XP_063136208.1  patatin-like phospholipase domain-containing protein 4 isoform X4

    5. XM_039100228.2XP_038956156.1  patatin-like phospholipase domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D4A227
      Conserved Domains (1) summary
      cd07222
      Location:5249
      Pat_PNPLA4; Patatin-like phospholipase domain containing protein 4
    6. XM_006256969.5XP_006257031.1  patatin-like phospholipase domain-containing protein 4 isoform X3

      See identical proteins and their annotated locations for XP_006257031.1

      Conserved Domains (1) summary
      cl11396
      Location:3191
      Patatin_and_cPLA2; Patatins and Phospholipases
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