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    Ntng1 netrin G1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295382, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ntng1provided by RGD
    Official Full Name
    netrin G1provided by RGD
    Primary source
    RGD:1563465
    See related
    EnsemblRapid:ENSRNOG00000031136 AllianceGenome:RGD:1563465
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563465
    Summary
    Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in several processes, including regulation of cell projection organization; regulation of neuron migration; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human NTNG1 (netrin G1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 56.6), Uterus (RPKM 30.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ntng1 in Genome Data Viewer
    Location:
    2q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (200151979..200515031, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (197462785..197827681, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (212695464..213073046, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene vav guanine nucleotide exchange factor 3 Neighboring gene uncharacterized LOC120100919 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120100921 Neighboring gene uncharacterized LOC102547648 Neighboring gene protein arginine methyltransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. Song YS, et al. J Cell Sci, 2013 Nov 1. PMID 23986473
    2. Complementary expression and neurite outgrowth activity of netrin-G subfamily members. Nakashiba T, et al. Mech Dev, 2002 Feb. PMID 11804778
    3. Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. Nakashiba T, et al. J Neurosci, 2000 Sep 1. PMID 10964959, Free PMC Article
    4. Netrin-G/NGL complexes encode functional synaptic diversification. Matsukawa H, et al. J Neurosci, 2014 Nov 19. PMID 25411505, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cell-cell adhesion mediator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    netrin-G1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106465.1 → NP_001099935.1  netrin-G1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A8I5ZNR9, A6HV45, F1LWK9
      Related
      ENSRNOP00000060409.4, ENSRNOT00000066218.4
      Conserved Domains (3) summary
      smart00180
      Location:420 → 467
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      200151979..200515031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590780.3 → XP_017446269.1  netrin-G1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GA33, A0A8I6GIB6, A6HV43
      Related
      ENSRNOP00000079843.2, ENSRNOT00000114999.2
      Conserved Domains (3) summary
      cd00054
      Location:373 → 397
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    2. XM_008761394.4 → XP_008759616.2  netrin-G1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ARQ4, A0A8I6GIB6, A6HV46
      Related
      ENSRNOP00000095580.1, ENSRNOT00000110142.2
      Conserved Domains (3) summary
      cd00054
      Location:395 → 419
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    3. XM_017590776.3 → XP_017446265.1  netrin-G1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARZ4, A6HV44
      Related
      ENSRNOP00000089707.2, ENSRNOT00000100896.2

    4. XM_017590779.3 → XP_017446268.1  netrin-G1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBS1, A0A8I6GIB6, A6HV47
      Related
      ENSRNOP00000076604.1, ENSRNOT00000117900.2
      Conserved Domains (3) summary
      cd00054
      Location:415 → 439
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)
    Nucleotide Protein Strain
    Heading Accession and Version

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