Mtf1 metal-regulatory transcription factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mtf1provided by RGD
Full Name: metal-regulatory transcription factor 1provided by RGD
Primary source: RGD:1308956
See related: EnsemblRapid:ENSRNOG00000025724 AllianceGenome:RGD:1308956
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 40.7), Brain (RPKM 40.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (142347024..142391810)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (137062319..137107136)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (142797340..142843896)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
Title: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of cartilage homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cadmium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metal regulatory transcription factor 1

Names: metal regulatory transcription factor 1-like; metal response element binding transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108677.1 → NP_001102147.1 metal regulatory transcription factor 1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6IS54, D3ZBT4

Related

ENSRNOP00000031224.4, ENSRNOT00000031928.6

Conserved Domains (3) summary

COG5048
Location:92 → 290

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:235 → 252

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:244 → 270

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

142347024..142391810

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238884.5 → XP_006238946.1 metal regulatory transcription factor 1 isoform X2

Conserved Domains (3) summary

COG5048
Location:92 → 290

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:235 → 252

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:244 → 270

zf-H2C2_2; Zinc-finger double domain
XM_063288017.1 → XP_063144087.1 metal regulatory transcription factor 1 isoform X2
XM_063288016.1 → XP_063144086.1 metal regulatory transcription factor 1 isoform X1

UniProtKB/TrEMBL

A6IS54, D3ZBT4
XM_039110342.2 → XP_038966270.1 metal regulatory transcription factor 1 isoform X3

Conserved Domains (2) summary

COG5048
Location:81 → 239

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:184 → 201

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_039110343.2 → XP_038966271.1 metal regulatory transcription factor 1 isoform X4

Conserved Domains (2) summary

COG5048
Location:76 → 241

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:174 → 191

ZF_C2H2; C2H2 Zn finger [structural motif]