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    Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk5r2provided by RGD
    Official Full Name
    cyclin-dependent kinase 5 regulatory subunit 2provided by RGD
    Primary source
    RGD:1562530
    See related
    AllianceGenome:RGD:1562530
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562530
    Summary
    Predicted to enable actin binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and protein kinase binding activity. Predicted to be involved in axon guidance and brain development. Predicted to act upstream of or within nervous system development; positive regulation of calcium ion-dependent exocytosis; and positive regulation of protein kinase activity. Located in cytoplasm; growth cone; and membrane. Orthologous to human CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk5r2 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83864922..83866390)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76416251..76417719)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82120059..82121527)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 10A Neighboring gene PCNA-associated factor-like Neighboring gene FEV transcription factor, ETS family member Neighboring gene crystallin, beta A2 Neighboring gene uncharacterized LOC134480387 Neighboring gene microRNA 375

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CDK5 activator, p39, binds specifically to myosin essential light chain. Ledee DR, et al. Biochem Biophys Res Commun, 2007 Mar 23. PMID 17276406, Free PMC Article
    2. Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. Lilja L, et al. J Biol Chem, 2004 Jul 9. PMID 15123626
    3. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. Humbert S, et al. J Cell Sci, 2000 Mar. PMID 10683146
    4. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. Ko J, et al. J Neurosci, 2001 Sep 1. PMID 11517264, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cerebellum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hippocampus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within layer formation in cerebral cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within superior olivary nucleus maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein kinase 5 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 5 activator 2
    Names
    cyclin-dependent kinase 5, regulatory subunit 2 (p39)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109309.1 → NP_001102779.1  cyclin-dependent kinase 5 activator 2

      See identical proteins and their annotated locations for NP_001102779.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474004
      UniProtKB/TrEMBL
      A6JVW4, F1M491
      Conserved Domains (1) summary
      pfam03261
      Location:174 → 329
      CDK5_activator; Cyclin-dependent kinase 5 activator protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83864922..83866390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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