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    Rnf152 ring finger protein 152 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293561, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf152provided by RGD
    Official Full Name
    ring finger protein 152provided by RGD
    Primary source
    RGD:1305251
    See related
    EnsemblRapid:ENSRNOG00000014859 AllianceGenome:RGD:1305251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein ubiquitination. Predicted to be located in lysosome and organelle membrane. Predicted to be active in lysosomal membrane. Orthologous to human RNF152 (ring finger protein 152). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 175.4), Brain (RPKM 56.1) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Rnf152 in Genome Data Viewer
    Location:
    13p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (21838634..21918000, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (21324039..21403405, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (25183295..25262785, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene high mobility group box 3, pseudogene 2 Neighboring gene cadherin 20 Neighboring gene uncharacterized LOC102547165 Neighboring gene uncharacterized LOC134481471 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables small GTPase binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid starvation  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in protein K48-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein monoubiquitination  
    involved_in protein monoubiquitination  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosome  
    located_in lysosome  
    located_in organelle membrane  
    located_in organelle membrane  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF152
    Names
    RING-type E3 ubiquitin transferase RNF152
    NP_001099775.1
    XP_017454255.1
    XP_017454256.1
    XP_017454257.1
    XP_017454258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106305.3NP_001099775.1  E3 ubiquitin-protein ligase RNF152

      See identical proteins and their annotated locations for NP_001099775.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      D4A723
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    2. NM_001429979.1NP_001416908.1  E3 ubiquitin-protein ligase RNF152

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      D4A723

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      21838634..21918000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598769.3XP_017454258.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      D4A723
      Related
      ENSRNOP00000095982.1, ENSRNOT00000107961.2
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    2. XM_017598766.3XP_017454255.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      Related
      ENSRNOP00000097172.1, ENSRNOT00000105662.2
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    3. XM_017598768.3XP_017454257.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      D4A723
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    4. XM_017598767.3XP_017454256.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      D4A723
      Related
      ENSRNOP00000093936.1, ENSRNOT00000102604.2
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
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