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    Wdr43 WD repeat domain 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362703, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr43provided by RGD
    Official Full Name
    WD repeat domain 43provided by RGD
    Primary source
    RGD:1565005
    See related
    EnsemblRapid:ENSRNOG00000026316 AllianceGenome:RGD:1565005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II complex binding activity and transcription elongation factor activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of RNA metabolic process; and regulation of stem cell population maintenance. Predicted to be located in chromatin; fibrillar center; and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human WDR43 (WD repeat domain 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 148.3), Spleen (RPKM 147.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Wdr43 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (29565610..29604954, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (23845499..23884846, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (23433532..23473179, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene photoreceptor cilium actin regulator Neighboring gene TOG array regulator of axonemal microtubules 2 Neighboring gene small nucleolar RNA, C/D box 53B Neighboring gene small nucleolar RNA, C/D box 53 Neighboring gene small nucleolar RNA, C/D box 92 Neighboring gene transfer RNA cysteine (anticodon GCA) 30 Neighboring gene speedy/RINGO cell cycle regulator family member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC116335

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromatin  
    located_in fibrillar center  
    is_active_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    part_of small-subunit processome  

    General protein information

    Preferred Names
    WD repeat-containing protein 43

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037791.2NP_001032880.2  WD repeat-containing protein 43

      See identical proteins and their annotated locations for NP_001032880.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZQB1, A6HA21, G3V920
      Related
      ENSRNOP00000033485.4, ENSRNOT00000035320.6
      Conserved Domains (4) summary
      COG2319
      Location:19217
      WD40; WD40 repeat [General function prediction only]
      pfam04003
      Location:473569
      Utp12; Dip2/Utp12 Family
      sd00039
      Location:1957
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:19271
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      29565610..29604954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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